Results 61 to 70 of about 473,580 (255)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

FACET-II facility for advanced accelerator experimental tests

Physical Review Accelerators and Beams, 2019
The National User Facility for Advanced Accelerator Experimental Tests II (FACET-II) at SLAC National Accelerator Laboratory expands upon the experiments conducted at FACET.
V. Yakimenko, L. Alsberg, E. Bong, G. Bouchard, C. Clarke, C. Emma, S. Green, C. Hast, M. J. Hogan, J. Seabury, N. Lipkowitz, B. O’Shea, D. Storey, G. White, G. Yocky   +14 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Soft X-ray tomography analysis of mitochondria dynamics in Saccharomyces cerevisiae

Biology Direct
Background Mitochondria are highly dynamic organelles that constantly undergo processes of fission and fusion. The changes in mitochondrial dynamics shape the organellar morphology and influence cellular activity regulation.
Wei-Ling Huang, Chang-Lin Chen, Zi-Jing Lin, Chia-Chun Hsieh, Mo Da-Sang Hua, Chih-Chan Cheng, Tzu-Hao Cheng, Lee-Jene Lai, Chuang-Rung Chang   +8 more
doaj   +1 more source

Analyses of the OSU-MASLWR Experimental Test Facility

Science and Technology of Nuclear Installations, 2012
Today, considering the sustainability of the nuclear technology in the energy mix policy of developing and developed countries, the international community starts the development of new advanced reactor designs. In this framework, Oregon State University
F. Mascari, G. Vella, B. G. Woods, F. D'Auria   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis

Respiratory Research
Background Transcriptome profiling by RNA sequencing (RNAseq) can provide insightful information on the molecular processes underlying disease development and progression.
Erica Ferrini, Costanza Bonfini, Giovanna Marchese, Martina Buccardi, Matteo Zoboli, Primetta Faccioli, Nicola Sverzellati, Gino Villetti, Simone Ottonello, Maria Ravo, Franco F. Stellari   +10 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Multidimensional lung imaging: integrated preclinical platforms enabling the identification of translational biomarkers for pulmonary research

Respiratory Research
Background Medical imaging is changing diagnostics, elucidating molecular disease mechanisms, supporting patient stratification, and advancing drug development toward personalized medicine across multiple therapeutic areas.
Francesca Pennati, Martina Buccardi, Andrea Aliverti, Erica Ferrini, Franco Fabio Stellari   +4 more
doaj   +1 more source