Results 81 to 90 of about 7,246,224 (296)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

A Tabu Search Heuristic Procedure for the Capacitated Facility Location Problem [PDF]

A tabu search heuristic procedure for the capacitated facility location problem is developed, implemented and computationally tested. The heuristic procedure uses both short term and long term memories to perform the main search process as well as the ...
Minghe Sun
core  

Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis

Respiratory Research
Background Transcriptome profiling by RNA sequencing (RNAseq) can provide insightful information on the molecular processes underlying disease development and progression.
Erica Ferrini, Costanza Bonfini, Giovanna Marchese, Martina Buccardi, Matteo Zoboli, Primetta Faccioli, Nicola Sverzellati, Gino Villetti, Simone Ottonello, Maria Ravo, Franco F. Stellari   +10 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The Single Row Facility Layout Problem: State of the Art [PDF]

The single row facility layout problem (SRFLP) is a NP-hard problem concerned with the arrangement of facilities of given lenghs on a line so as to minimize the weighted sum of the distances between all the pairs of facilities.
Kothari, Ravi, Ghosh, Diptesh
core  

Lagrangian relaxation heuristics for the uncapacitated single-source multi-product facility location problem [PDF]

, 2013
Facility location problem is one of the strategic logistical drivers within the supply chain which is a hard to solve optimization problem. In this study, we focus on the uncapacitated single-source multi-product production/distribution facility location
Nezhad, Ali Mohammad, Manzour, Hasan, Salhi, Said   +2 more
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Oxbow Experimental Incubation Facility Operation 1963-64

, 1964
A summary of operations at the Oxbow Experimental Incubation Facility from September 3, 1963 through June 10, 1964.19 ...
Craig, Garrett, Fish and Game, Idaho Dept. of, Div. of Fisheries;   +1 more
core  

Development of the HITRAP experimental facility

, 2014
GSI Scientific Report 2013 - GSI Report 2014 ...
Andelkovic, Z., Fedotova, S., Herfurth, F., Kotovskiy, N., Maaß, B., Steinmann, J., Vorobjev, G.   +6 more
openaire   +2 more sources

Multidimensional lung imaging: integrated preclinical platforms enabling the identification of translational biomarkers for pulmonary research

Respiratory Research
Background Medical imaging is changing diagnostics, elucidating molecular disease mechanisms, supporting patient stratification, and advancing drug development toward personalized medicine across multiple therapeutic areas.
Francesca Pennati, Martina Buccardi, Andrea Aliverti, Erica Ferrini, Franco Fabio Stellari   +4 more
doaj   +1 more source