Results 241 to 250 of about 6,869,290 (307)

Human-like conversational agents as social partners: a scoping review of socioaffective mechanisms, well-being outcomes, risks and governance in the post-Turing era. [PDF]

Front Artif Intell
Li Q, Geng H, Hu X, Pan D, Liu H, Li Y, Guo J.   +6 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Trustworthy and ethical intrusion detection for healthcare internet of medical things using reinforcement learning and governance rules. [PDF]

Sci Rep
Adabara I, Sadiq BO, Shuaibu AN, Danjuma YI, Maninti V, Joe M.   +5 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Translational assessment instruments for preclinical to first-in-human decision-making: a scoping review. [PDF]

J Transl Med
Straccia M, Azilagbetor DM, Camp C, Ferreira GS, Garcia-Bermejo ML, Gastaldello A, Gurusamy K, Pappalardo F, Ritskes-Hoitinga MJ, Rossi F, Tagle D, Wehling M, Pistollato F.   +12 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Rethinking governance of synthetic cells. [PDF]

Front Bioeng Biotechnol
Gillum DR, Carr PA, Hook-Barnard I, Tucholski T.   +3 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Governance models for cultural assets owned by public healthcare organizations: Italian and Portuguese experiences. [PDF]

Front Public Health
Persiani N, Landini G, José H.
europepmc   +1 more source

GSH-responsive polyurethane/PBAT blend films: degradation kinetics, ecotoxicity screening, and governance-carbon coupling <i>via</i> three-tier mapping. [PDF]

RSC Adv
Zeng J, Zhang M, An B.
europepmc   +1 more source