Results 161 to 170 of about 11,675,419 (289)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A phase 1 experimental medicine study of anti-CD3 monoclonal antibody in rheumatoid arthritis. [PDF]

Immunother Adv
Lawson CA, Harry R, Griffiths B, Hale G, Waldmann H, Isaacs JD.   +5 more
europepmc   +1 more source

An experimental medicine study of the effects of simvastatin on emotional processing, reward learning, verbal memory, and inflammation in healthy volunteers. [PDF]

Psychopharmacology (Berl), 2022
De Giorgi R, Quinton AMG, Waters S, Cowen PJ, Harmer CJ.   +4 more
europepmc   +1 more source

Procedures in emergency medicine: oropharyngeal airway insertion

, 2013
This video is part of a series of videos demonstrating common procedures performed in the Emergency Medicine setting. It was prepared by Cape Town Emergency Medicine's consultants and registrars. This short simulated video demonstrates the technique of
Oosthuizen, Almero, Cape Town Emergency Medicine Registrars   +1 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

PCOS and Inositols – Advances and Lessons We are Learning. A Narrative Review

Drug Design, Development and Therapy
Guglielmo Lentini, Alessandro Querqui, Noemi Monti, Mariano Bizzarri Department of Experimental Medicine, Space Biomedicine Laboratory, University Sapienza, Rome, ItalyCorrespondence: Mariano Bizzarri, Email mariano.bizzarri@uniroma1.itIntroduction: This
Lentini G, Querqui A, Monti N, Bizzarri M   +3 more
doaj  

Aetiology of type 2 diabetes: an experimental medicine odyssey. [PDF]

Diabetologia
Taylor R.
europepmc   +1 more source

In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies. [PDF]

Cereb Cortex, 2021
Shaw AD, Hughes LE, Moran R, Coyle-Gilchrist I, Rittman T, Rowe JB.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon-like peptide-1 and glucagon receptor in healthy subjects. [PDF]

Br J Clin Pharmacol
Goodman J, Parker VE, McEniery CM, Di Stefano G, Hubsch A, Vamvaka E, Helmy J, Kaloyirou F, Jalaludeen N, Barker P, Jermutus L, Cheriyan J, Ambery P, Wilkinson IB.   +13 more
europepmc   +1 more source