Results 131 to 140 of about 26,846,501 (291)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Research of the Dynamic Characteristic Analysis of Auto Transmission Housing

Jixie chuandong, 2016
To understand the structure dynamic characteristic problem of a certain type auto transmission housing,taking the type auto transmission housing as the research object,the modal simulation analysis and the experimental modal analysis are respectively ...
Meng Fanlong, Ma Weijin, Zhang Jiping, Luo Chaoyang, Yang Wei, Zhang Yanlong   +5 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Modal investigation of an office building floor

, 1998
Procedures and results of an experimental and analytical Modal investigation performed on an 8.6 x 25.8 m office building floor are presented. This floor is part of a lightweight steel construction added inside of an existing 8 m high large steel frame ...
Deger, Y. (author), Pietrzko, S. (author), Cantieni, R. (author)   +2 more
core   +1 more source

Experimental investigation of dynamic characteristics of basalt fiber composite plates using impact-based modal analysis

Journal of Engineering and Applied Science
Basalt fiber reinforced polymer(BFRP) also composite are widely used in the lightweight structure construction because of their stiffness, durability and environmental resistance.
Pankaj Gupta, Ali B. M. Ali, Palkesh Maithil, Mohammad Amir Khan, Ahmed A. Alamiery, Aseel Smerat   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Bayesian oma of offshore rock lighthouses: Surprises with close modes, symmetry and alignment

, 2019
A set of seven rock lighthouses around the British Isles was studied by a combination of forced and ambient vibration tests executed with some extreme logistical constraints.
Au, Siu Kui (author), Antonini, A. (author), Raby, Alison (author), Brownjohn, James (author), Zhu, Zuo (author), Wang, Xinrui (author)   +5 more
core  

Experimental Damping Identification of a Bridge Case Study in Norway under Still Air Conditions [PDF]

Aeroelastic effects are a fascinating yet problematic phenomenon that lies in between the ®elds of aero nautical and bridge engineering, as many long-span bridge decks show dynamic behaviors similar to the ones of wing airfoils when met with strong winds.
Rosso, Marco Martino, Marano, Giuseppe C., Dessena, Gabriele, Civera, Marco, Chiaia, Bernardino   +4 more
core   +5 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source