Results 171 to 180 of about 34,125,379 (266)

Adverse Cardiometabolic Impacts of Sleep Fragmentation and Estradiol Suppression: An Experimental Model of Menopause. [PDF]

J Clin Endocrinol Metab
Rahman SA, Grant LK, Cohn AY, Harder JA, Nathan MD, Gonsalvez I, Wiley A, Mora S, Taylor JA, Scheer FAJL, Klerman EB, Kaiser UB, Crawford S, Joffe H.   +13 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Assessment of the efficiency of new regenerative gel and spray in experimental model systems. [PDF]

BMC Pharmacol Toxicol
Bezdieniezhnykh N, Lykhova O, Borshchevska M, Goy A, Saulenko K, Kozak T, Kukurudza D, Kruglov Y, Borshchevskiy G, Buchynska L.   +9 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hemorheological and microcirculatory effects of Pentaglobin therapy in an experimental model of fulminant sepsis. [PDF]

Front Physiol
Matrai AA, Ujhelyi B, Varga A, Zahorszki SR, Adorjan DM, Toth Z, Nemeth N, Fulesdi B, Deak A.   +8 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Effects of <i>Physalis philadelphica</i> Lam. Husk Infusion on Obesity and Associated Metabolic Disturbances in an Experimental Model. [PDF]

Int J Mol Sci
Gamboa-Gómez CI, Barragán-Zúñiga J, Guerra-Rosas MI, Gónzalez JL, Sayago-Monreal VI, Castillo-López CP, Valles-Araiza KF, Alvarado-Aguilar A, Morales-Castro J, Rodríguez-Morán M, Guerrero-Romero F.   +10 more
europepmc   +1 more source

Scleral changes induced by atropine in chicks as an experimental model of myopia

Ophthalmic & physiological optics, 2012
P. Gallego, C. Martínez-García, P. Pérez-Merino, L. Ibarés-Fŕıas, A. Mayo-Íscar, J. Merayo-Lloves   +5 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effects of carnosic acid on renal injury-related parameters and iNOS immunoreactivity in an experimental model of contrast-associated acute kidney injury. [PDF]

Ren Fail
Küçükyağcı N, Salt Ö, Sayhan MB, Aydoğdu N, Taştekin E, Çeliktürk E, Seçgin Sayhan E.   +6 more
europepmc   +1 more source