Results 221 to 230 of about 8,617,954 (300)

Restorative potential of melatonin during treatment of severe scabies in an experimental model. [PDF]

Parasitol Res
Sharaf MS, Othman AA, Ali DM, Hafez AM, Ellakany AR.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Advancing forest pathology: the need for community-driven molecular experimental model systems. [PDF]

New Phytol
Oostlander AG, Fleißner A, Slippers B.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Benznidazole therapy improves pressure overload and cardiac electrical profile in an experimental model of Angiotensin II infusion-induced hypertension: Mechanistic insights. [PDF]

PLoS One
da Silva Pinheiro AP, Vilar-Pereira G, Castaño-Barrios L, Peroba Rezende Ramos I, Pedra-Rezende Y, Dantas-Pereira L, Figueiredo Sadok Menna-Barreto R, Gibaldi D, Mata-Santos HA, Lannes-Vieira J.   +9 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

D-cycloserine effects on COPD and depression in a murine experimental model. [PDF]

Front Pharmacol
Heresco-Levy U, Haviv J, Caine YG, Bao J, Huang TY, Shen CC, Bogot NR.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Comparative Study of [¹⁸F]DPA714 and [¹⁸F]FDG PET Tracers in an Experimental Model of Pulmonary Tuberculosis. [PDF]

Mol Imaging Biol
Stammes MA, Vierboom MPM, Sombroek CC, Bakker J, Meijer L, Vervenne RAW, Hofman SO, Nutma E, Kondova I, Windhorst AD, Langermans JAM, Verreck FAW.   +11 more
europepmc   +1 more source