Results 131 to 140 of about 2,221,895 (307)

1331 Cancer vaccine development based on molecular mimicry

Journal for ImmunoTherapy of Cancer, 2023
Luigi Buonaguro, Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Experimental models to study glycoconjugate modifications in malignant transformation

, 1997
Experimental models to study glycoconjugate modifications in malignant ...
S. Rapelli, G. Montorfano, E. Monteggia, L. Adorni, B. Berra, I. Colombo, E. Sottocornola   +6 more
core  

Analysis and selection of experimental models of osteoarthritis

, 2014
Aim. The aim of the work is to examine relevant literature on different patterns of experimental osteoarthritis and choose the most acceptable one for providing its preclinical investigation. Methods and results.
O. V. Monina, E. R. Skakovsky, O. A. Grygorieva   +2 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Experimental Models of Acinetobacter Infection

, 2008
The use of animals as models for microbiological infections is a fundamental part of infectious disease research. The intent for the use of animals as models of disease is to establish an infection that mimics that seen in humans (Druilhe et al., 2002 ...
Marie Laure Joly-Guillou, Wolff, Michel, Michel Wolff, Joly-Guillou, Marie-Laure   +3 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Experimental Models of Schistosoma mansoni   Infection

, 2002
Experimental models of Schistosoma mansoni   infections in mammals have contributed greatly to our understanding of the pathology and pathogenesis of infection. We consider here hepatic and extrahepatic disease in models of acute and chronic infection.
Jane A Lenzi, Zilton A Andrade, Allen W Cheever, Henrique L Lenzi   +3 more
core   +1 more source

An Experimental Model of Myocardial and Cerebral Global Ischemia and Reperfusion

, 2011
Despite many programs aimed at better immediate care of cardiac arrest victims, the subsequent mortality rate remains high, with myocardial and central nervous system injuries as the most common causes of death.
Lars Wiklund, Basu, Samar,, Samar Basu, Wiklund, Lars,   +3 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source