Results 141 to 150 of about 2,221,895 (307)

Innovative models to explore hepatic involvement in Prader-Willi syndrome

Frontiers in Endocrinology
Prader-Willi syndrome (PWS; MIM# 176270) is a rare neurodevelopmental disorder characterized by clinical manifestations across multiple body systems.
Romar Guintu Dabban, Romar Guintu Dabban, Romar Guintu Dabban, Graziano Grugni, Adele Bondesan, Benedetta Blarasin, Benedetta Blarasin, Claudio Tiribelli, Cristina Bellarosa, Alessandro Sartorio   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effect of PM2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens

Scientific Reports
Fine particulate matter 2.5 (PM2.5) is a prevalent atmospheric pollutant that is closely associated with asthma. Elderly patients have a high incidence of asthma with a long course of illness.
Lianlian Zhao, Xiaolin Ding, Li Zhou, Chenchen Song, Taisheng Kang, Yanfeng Xu, Yunpeng Liu, Yunlin Han, Wenjie Zhao, Boxiang Zhang, Dan Xu, Jianguo Guo   +11 more
doaj   +1 more source

Measuring Oxidative Stress in Cell Cultures, Animals and Humans: Analysis and Validation of Oxidatively Damaged DNA

, 2011
An association between oxidative stress and different diseases has been described in the literature, but there are obvious shortcomings with methods available to assess oxidative stress.
Hanna L. Karlsson, Karlsson, HL, Möller, L, Lennart Möller   +3 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

High expression of SULF1 is associated with adverse prognosis in breast cancer brain metastasis

Animal Models and Experimental Medicine
Background Breast cancer is the most common cancer in women, and in advanced stages, it often metastasizes to the brain. However, research on the biological mechanisms of breast cancer brain metastasis and potential therapeutic targets are limited ...
Yitong Li, Tingting Feng, Qinghong Wang, Yue Wu, Jue Wang, Wenlong Zhang, Qi Kong   +6 more
doaj   +1 more source

Experimental models of heart failure.

, 2004
To properly assess mechanisms of heart failure a test new effective interventions adequate experimental models are needed. Specifically, as far as heart failure concerns the use of chronic preparation is fundamental. Also mechanisms of HF inductions must
Pentimalli F, 2. Vanoli E, Bacchini S, Adamson Pb, VANOLI, EMILIO, Panigada S   +5 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source