Results 81 to 90 of about 1,454,596 (276)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

TMX upgrade experimental operating plan [PDF]

open access: yes, 1981
This document describes the operating plan for the TMX Upgrade experiment. This plan covers the period from November 1981 to March 1983 and describes how the TMX will be brought into operation, our schedules and milestones, and how we will determine if the TMX Upgrade program milestones have been met.
Coensgen, F. H.   +2 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

SPRD: a surface plasmon resonance database of common factors for better experimental planning. [PDF]

open access: yesBMC Mol Cell Biol, 2021
Tiwari PB   +6 more
europepmc   +1 more source

Hierarchical D ∗ algorithm with materialization of costs for robot path planning [PDF]

open access: yes, 2005
In this paper a new hierarchical extension of the D ∗ algorithm for robot path planning is introduced. The hierarchical D ∗ algorithm uses a down-top strategy and a set of precalculated paths (materialization of path costs) in order to improve ...
Cagigas Muñiz, Daniel
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

PLOT SIZE IN THE EVALUATION OF PAPAYA SEEDLINGS 'BAIXINHO DE SANTA AMÁLIA' IN TUBES

open access: yesRevista Brasileira de Fruticultura
Were evaluated three characters in papaya seedlings 'Baixinho de Santa Amália' to estimate the optimum plot size and the number of replications in a completely randomized experiment, a randomized block and Latin square.
HUMBERTO FELIPE CELANTI   +4 more
doaj   +1 more source

National Ignition Facility: Experimental plan [PDF]

open access: yes, 1994
As part of the Conceptual Design Report (CDR) for the National Ignition Facility (NIF), scientists from Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Sandia National Laboratory (SNL), the University of Rochester`s Laboratory for Laser Energetics (UR/LLE), and EG&G formed an NIF Target Diagnostics Working Group ...
openaire   +2 more sources

Interactive experimenters' planning procedures and mission control [PDF]

open access: yes
The computerized mission control and planning system routinely generates a 24-hour schedule in one hour of operator time by including time dimensions into experimental planning procedures.
Desjardins, R. L.
core   +1 more source

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