Results 121 to 130 of about 10,375,225 (321)

Opportunities From Precision Flavour Physics [PDF]

, 2009
The possible role of precision flavour physics, and particularly of B physics, in the next decade is briefly discussed. Few 2--3$\sigma$ deviations from the Standard Model found in present $B$ data are reviewed as potential forerunners of new physics ...
Ciuchini, Marco
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Experimental planning for the evaluation of phenotipic descriptors in banana

Revista Brasileira de Fruticultura, 2018
This work aimed to subsidize experimental planning for the evaluation of phenotypic characters in banana. The experiment consisted of a uniformity trial with Tropical cultivar spaced of 3 m x 2 m, in a useful area with nine rows of 40 plants.
Sérgio Luiz Rodrigues Donato, João Abel da Silva, Bruno Vinícius Castro Guimarães, Sebastião de Oliveira e Silva   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Índice de heterogeneidade, coeficiente de variação e tamanho ótimo de parcela em batata Heterogeneity index, variation coefficient and optimal potato plot size

Ciência Rural, 2006
O objetivo deste trabalho foi avaliar a relação entre o coeficiente de variação das parcelas de uma cova e o índice de heterogeneidade com o tamanho ótimo de parcela para experimentos com batata.
Sérgio José Ribeiro de Oliveira, Lindolfo Storck, Alessandro Dal'Col Lúcio, Sidinei José Lopes, Luiz Fernando Dias Martini   +4 more
doaj   +1 more source

Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy

Clinical Cancer Research, 2016
Purpose: The tumor microenvironment is formed by many distinct and interacting cell populations, and its composition may predict patients' prognosis and response to therapies.
E. Becht, A. de Reyniès, Nicolas A. Giraldo, C. Pilati, Bénédicte Buttard, L. Lacroix, J. Selves, C. Sautès-Fridman, P. Laurent-Puig, W. Fridman   +9 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Tamanho de amostra para experimentos com feijão-de-vagem em diferentes ambientes Sample size for experiments with bean pods in different environments

Ciência Rural, 2011
Com o objetivo de estimar o tamanho de amostra para a fitomassa fresca de vagens de feijão-de-vagem, foram realizados cinco experimentos em branco com a cultivar 'Macarrão' no outono/inverno de 2009 e na primavera/verão de 2010, em estufa, túnel e a ...
Fernando Machado Haesbaert, Daniel Santos, Alessandro Dal’Col Lúcio, Vilson Benz, Bruno Ioppi Antonello   +4 more
doaj   +1 more source

Studies on the electromagnetic structure of the nucleon by free and quasi-free Compton scattering at MAMI (Mainz)

, 2002
Using hydrogen and deuterium targets, Compton scattering by the proton and neutron have been studied at the tagged photon beam of the MAMI (Mainz) accelerator using different experimental setups. The theoretical tools for the analysis of the experimental
Babusci, Bernard, Camen, Enik, Galler, Grießhammer, Kossert, L'vov, L'vov, Lee, Lee, Lee, Levchuk, Levchuk, Martin Schumacher, Olmos de León, Rose, Rose, Schmiedmayer, Wissman, Wolf   +20 more
core   +1 more source

A precision sprayer capable of whole-of-block precision experimentation in viticulture

The French Wine and Vine Institute and INRAE have developed innovative methods to study the factors of plant protection product efficacy under real vineyard conditions, employing whole-of-block precision experimentation principles. From 2021 to 2023, a partnership with OPTIMA Concept ® and Berthoud ® allowed to develop a high-precision sprayer tailored
Codis, Sébastien, Delpuech, Xavier, Lewis, Maude, Bellone, Davide, Ribeyrolles, Xavier, Vergès, Adrien, Naud, Olivier   +6 more
openaire   +2 more sources