Results 101 to 110 of about 1,746,635 (298)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Melhoria na eficiência dos experimentos de indicalção de cultivares de milho Enhanced efficicency in experiments for maize cultivar indication

Ciência e Agrotecnologia, 2006
Objetivou-se com este trabalho verificar o comportamento da precisão experimental mediante o uso de métodos de correção de produtividade das parcelas experimentais e suas influências sobre a comparação e indicação de cultivares de milho pelo método de ...
Edilson Romais Schmildt, Willian Krause, Cosme Damião Cruz   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental planning for the evaluation of phenotipic descriptors in banana

Revista Brasileira de Fruticultura, 2018
This work aimed to subsidize experimental planning for the evaluation of phenotypic characters in banana. The experiment consisted of a uniformity trial with Tropical cultivar spaced of 3 m x 2 m, in a useful area with nine rows of 40 plants.
Sérgio Luiz Rodrigues Donato, João Abel da Silva, Bruno Vinícius Castro Guimarães, Sebastião de Oliveira e Silva   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Índice de heterogeneidade, coeficiente de variação e tamanho ótimo de parcela em batata Heterogeneity index, variation coefficient and optimal potato plot size

Ciência Rural, 2006
O objetivo deste trabalho foi avaliar a relação entre o coeficiente de variação das parcelas de uma cova e o índice de heterogeneidade com o tamanho ótimo de parcela para experimentos com batata.
Sérgio José Ribeiro de Oliveira, Lindolfo Storck, Alessandro Dal'Col Lúcio, Sidinei José Lopes, Luiz Fernando Dias Martini   +4 more
doaj   +1 more source

Quantum Metrology with Cold Atoms

, 2013
Quantum metrology is the science that aims to achieve precision measurements by making use of quantum principles. Attribute to the well-developed techniques of manipulating and detecting cold atoms, cold atomic systems provide an excellent platform for ...
Huang, Jiahao, Lee, Chaohong, Wu, Shuyuan, Zhong, Honghua   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Tamanho de amostra para experimentos com feijão-de-vagem em diferentes ambientes Sample size for experiments with bean pods in different environments

Ciência Rural, 2011
Com o objetivo de estimar o tamanho de amostra para a fitomassa fresca de vagens de feijão-de-vagem, foram realizados cinco experimentos em branco com a cultivar 'Macarrão' no outono/inverno de 2009 e na primavera/verão de 2010, em estufa, túnel e a ...
Fernando Machado Haesbaert, Daniel Santos, Alessandro Dal’Col Lúcio, Vilson Benz, Bruno Ioppi Antonello   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source