Results 101 to 110 of about 10,600,838 (308)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Melhoria na eficiência dos experimentos de indicalção de cultivares de milho Enhanced efficicency in experiments for maize cultivar indication

Ciência e Agrotecnologia, 2006
Objetivou-se com este trabalho verificar o comportamento da precisão experimental mediante o uso de métodos de correção de produtividade das parcelas experimentais e suas influências sobre a comparação e indicação de cultivares de milho pelo método de ...
Edilson Romais Schmildt, Willian Krause, Cosme Damião Cruz   +2 more
doaj   +1 more source

PTEN-opathies: from biological insights to evidence-based precision medicine.

Journal of Clinical Investigation, 2019
The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN hamartoma tumor syndrome (PHTS), featuring various benign and malignant tumors, as well ...
L. Yehia, J. Ngeow, C. Eng
semanticscholar   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Experimental planning for the evaluation of phenotipic descriptors in banana

Revista Brasileira de Fruticultura, 2018
This work aimed to subsidize experimental planning for the evaluation of phenotypic characters in banana. The experiment consisted of a uniformity trial with Tropical cultivar spaced of 3 m x 2 m, in a useful area with nine rows of 40 plants.
Sérgio Luiz Rodrigues Donato, João Abel da Silva, Bruno Vinícius Castro Guimarães, Sebastião de Oliveira e Silva   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Índice de heterogeneidade, coeficiente de variação e tamanho ótimo de parcela em batata Heterogeneity index, variation coefficient and optimal potato plot size

Ciência Rural, 2006
O objetivo deste trabalho foi avaliar a relação entre o coeficiente de variação das parcelas de uma cova e o índice de heterogeneidade com o tamanho ótimo de parcela para experimentos com batata.
Sérgio José Ribeiro de Oliveira, Lindolfo Storck, Alessandro Dal'Col Lúcio, Sidinei José Lopes, Luiz Fernando Dias Martini   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Optimization of the assessment of anthracnose severity in artificially inoculated common beans

Crop Breeding and Applied Biotechnology
The aim was to estimate the minimum number of plants required per plot to assess the anthracnose severity by artificial inoculation of V2 stage plants. Seventy-eight carioca common bean cultivars were inoculated in 13 experiments to assess its reaction ...
Jussara Mencalha, Mariana Andrade Dias, Elaine Aparecida de Souza, Vinicius Quintão Carneiro, Fernanda Aparecida Castro Pereira, Pedro Crescêncio Souza Carneiro, José Eustáquio de Souza Carneiro   +6 more
doaj  

Tamanho de amostra para experimentos com feijão-de-vagem em diferentes ambientes Sample size for experiments with bean pods in different environments

Ciência Rural, 2011
Com o objetivo de estimar o tamanho de amostra para a fitomassa fresca de vagens de feijão-de-vagem, foram realizados cinco experimentos em branco com a cultivar 'Macarrão' no outono/inverno de 2009 e na primavera/verão de 2010, em estufa, túnel e a ...
Fernando Machado Haesbaert, Daniel Santos, Alessandro Dal’Col Lúcio, Vilson Benz, Bruno Ioppi Antonello   +4 more
doaj   +1 more source