Results 131 to 140 of about 10,375,225 (321)

Balancing Precision and Retention in Experimental Design

Political Analysis
Abstract In experimental social science, precise treatment effect estimation is of utmost importance, and researchers can make design choices to increase precision. Specifically, block-randomized and pre-post designs are promoted as effective means to increase precision.
Gustavo Diaz, Erin Rossiter
openaire   +1 more source

PTEN-opathies: from biological insights to evidence-based precision medicine.

Journal of Clinical Investigation, 2019
The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN hamartoma tumor syndrome (PHTS), featuring various benign and malignant tumors, as well ...
L. Yehia, J. Ngeow, C. Eng
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Electromagnetic Form Factors of the Nucleon and Compton Scattering

, 2005
We review the experimental and theoretical status of elastic electron scattering and elastic low-energy photon scattering (with both real and virtual photons) from the nucleon. As a consequence of new experimental facilities and new theoretical insights,
Akhiezer AI, Baranov PS, Baylac M, Brooks W, Brooks W, Cardman LS, Charles Earl Hyde-Wright, Derbenev YaS, Enik TL, Gerasimov SB, Gol'danski VI, Kees de Jager, L'vov AI, Petrunkin VA   +13 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

PLOT SIZE IN THE EVALUATION OF PAPAYA SEEDLINGS 'BAIXINHO DE SANTA AMÁLIA' IN TUBES

Revista Brasileira de Fruticultura
Were evaluated three characters in papaya seedlings 'Baixinho de Santa Amália' to estimate the optimum plot size and the number of replications in a completely randomized experiment, a randomized block and Latin square.
HUMBERTO FELIPE CELANTI, OMAR SCHMILDT, RODRIGO SOBREIRA ALEXANDRE, LAERCIO FRANCISCO CATTANEO, EDILSON ROMAIS SCHMILDT   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Tamanho de amostra para estimação do coeficiente de correlação de Pearson entre caracteres de Crambe abyssinica Sample size to estimate the Pearson correlation coefficient among characters of Crambe abyssinica

Revista Ciência Agronômica, 2011
É importante dimensionar adequadamente o tamanho de amostra, para estimação, com confiabilidade aceitável, do coeficiente de correlação linear de Pearson entre pares de caracteres.
Alberto Cargnelutti Filho, Sidinei José Lopes, Marcos Toebe, Tatiani Reis da Silveira, Ismael Albino Schwantes   +4 more
doaj   +1 more source

Site-specific treatment responses in on-farm precision experimentation

, 2019
There is a large body of research on determining the impact of field variability of soil on crop yields. In contrast, site-specific information about crop responses to agronomic treatments is less frequent. On-Farm Precision Experimentation (OFPE) brings important information to understand the spatial variation of crop response to agronomic practices ...
Rodrigo Gonçalves Trevisan, David S. Bullock, Nicolas Federico Martin   +2 more
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source