Results 171 to 180 of about 10,375,225 (321)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A Case of Nocardia kroppenstedtii Infection Successfully Treated With a Multidisciplinary Approach

Case Reports in Infectious Diseases
Nocardia species constitute a diverse group of microorganisms classified as aerobic actinomyces. Among these species, many have been implicated as causative agents of severe human infections, particularly in immunocompromised patients, affecting lungs ...
Francesco Foglia, Annalisa Ambrosino, Giuseppe Greco, Annalisa Chianese, Carla Zannella, Francesca Cinone, Alfonso Reginelli, Diego Sandro Giordano, Giovanni Tortorella, Maria Teresa Laieta, Anna De Filippis, Massimiliano Galdiero, Rita Greco, Emiliana Finamore   +13 more
doaj   +1 more source

Electroweak Precision Data - Global Higgs Analysis

, 2003
The status of published and preliminary precision electroweak measurements as of winter 2002/03 is presented. The new results on the mass of the W boson as measured at LEP-2 and on atomic parity violation in Caesium are included. The experimental results
Grunewald, Martin W.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Número de repetições para a comparação de cultivares de milho Number of replications for the comparison in corn cultivars

Ciência Rural, 2010
O objetivo deste trabalho foi determinar o número de medições (repetições) necessárias à predição do desempenho de cultivares de milho (Zea mays L.). Para isso, foram usados os dados de produtividade de grãos de 286 ensaios de competição de cultivares ...
Alberto Cargnelutti Filho, Lindolfo Storck, José Paulo Guadagnin   +2 more
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Classification of the coefficients of variation for sugarcane crops Classificação dos coeficientes de variação para a cultura da cana de açúcar

Ciência Rural, 2013
The objective of this paper was to evaluate the range of classification of variation coefficient in experiments with sugarcane. For this study, some of the variables that are mostly used by researchers of the culture were considered.
Mauricio Farias Couto, Luiz Alexandre Peternelli, Márcio Henrique Pereira Barbosa   +2 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source