Results 161 to 170 of about 10,498,087 (284)

Experimental research on the fire resistance of columns in container-style steel modular buildings. [PDF]

Sci Rep
Duan J, Liu J, Wei J, Wu H, Gao S.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Analysis on hydraulic dynamic stiffness characteristics and experimental research of asymmetric valve-controlled asymmetric cylinder system. [PDF]

Sci Rep
Weiwei L, He Yong H, Chuiyi L.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Numerical simulation and experimental research on the oil removal efficiency during the oily wastewater separation by hydrocyclone. [PDF]

Sci Rep
Shuai Z, Weili Z, Laiyuan D, Dejun K, Wenwen Y.   +4 more
europepmc   +1 more source

Experimental Research of Electrical Resistance in a Bubbling Fluidized Bed [PDF]

, 2014
Fedorov, S.S., Nikitina, I.P., Seleznev, Igor   +2 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A quasi-experimental research on developing students' life skills through purposeful leisure time activities. [PDF]

Front Psychol
Koçak GN, Çetin MÇ, Kara M, Genç M, Lekesiz G, Açıkbaş FC, Kara NŞ.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cocaine Cues Used in Experimental Research: A Systematic Review. [PDF]

Brain Sci
Brobbin E, Lowry N, Cella M, Copello A, Coulton S, Di Pietro J, Drummond C, Glautier S, Kiyak C, Phillips T, Stahl D, Starr S, Valmaggia L, Williams C, Deluca P.   +14 more
europepmc   +1 more source