Results 151 to 160 of about 58,403,547 (305)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
National Mental Health Research Strategy [PDF]
This first national mental health research strategy for Ireland presents a unique opportunity to create a thriving mental health research system that can support mental health and wellbeing for all.
Health Research Board
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Nonconventional Technologies Review, 2015 In a world where minimizing tendency is everywhere, the necessity of obtaining surfaces of small dimensions, but with similar properties and reliability as those with regular dimensions is evident.
Stefan Stoica +4 more
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
NEWS AND INSIGHTS INTO DIMENSIONAL PROCESSING THROUGH ELECTRICAL DISCHARGE MACHINING
Nonconventional Technologies Review, 2015 The scientific paper presents an experimental research focused in final on the obtained experimental data processing. We can talk about modeling and subsequent about the optimization of the process parameters considering the actual situation.
Mihail Aurel Titu
doaj
Memoria de la Estación Experimental de Aula Dei. 2005. [PDF]
, 2006 CSIC - Estación Experimental de Aula Dei (EEAD)
core +1 more source