Results 231 to 240 of about 10,498,087 (284)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Exploring the effects of long-term physical exercise on persistent and inhibitory self-control: quasi-experimental research. [PDF]

Front Sports Act Living
Cheng L, Qin H, Yang Y, Dang J.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Simulation and experimental research on drilling and rock breaking mechanisms of anchor drill rigs with analysis of drilling feedback signals. [PDF]

Sci Rep
Wang XH, Zhao ZQ, Jing W.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Emerging trends and hotspots in animal experimental research on lung transplantation from 2004 to 2023: a bibliometric analysis. [PDF]

J Thorac Dis
Xie C, Piao M, Zhou L, Tao X, Yao Y, Jiang B, Wang X, Yan M.   +7 more
europepmc   +1 more source

Experimental Research on Gradation Range and Performance of SMAC13. [PDF]

Materials (Basel)
Zhen Q, Cao W, Dong R, Liu S, Liu N, Zhan Z, Li Y.   +6 more
europepmc   +1 more source

Experimental Research on the Performance of Recycled Waste Concrete Powder (RWCP) on Concrete. [PDF]

Materials (Basel)
Wang S, Wang A, Fu X, Zhang X, Zhang X, Li Z, Guo Y, Li S, Wang M.   +8 more
europepmc   +1 more source

Experimental research on remote non-contact laser vibration measurement for tunnel lining cavities. [PDF]

Sci Rep
Yang H, Xie Y, Lin Z, Li L, Chen X, Feng W, Ran H, He L.   +7 more
europepmc   +1 more source

Critical key points for anesthesia in experimental research involving sheep (Ovis aries). [PDF]

Open Vet J
Costea R, Iancu T, Duțulescu A, Nicolae C, Leau F, Pavel R.   +5 more
europepmc   +1 more source