Results 81 to 90 of about 10,498,087 (284)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Experimental study of the pharmacokinetics of monoclonal antibodies to α4β1-integrin in guinea pigs

Биопрепараты: Профилактика, диагностика, лечение, 2018
This article presents the data on pharmacodynamics evaluation of monoclonal antibodies to α4β1-integrin in guinea pigs. The effect on total content of peripheral blood leukocytes after a single intraperitoneal injection of three doses of the drug has ...
B. N. Krapivin, O. V. Goncharova, E. L. Morozova   +2 more
doaj  

Otto Stern (1888-1969): The founding father of experimental atomic physics

, 2011
We review the work and life of Otto Stern who developed the molecular beam technique and with its aid laid the foundations of experimental atomic physics.
Friedrich, Bretislav, Lower, Julian C. A., Schmidt-Böcking, Horst, Toennies, J. Peter   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Estimation of Uniaxial Compressive Strength and Tensile Strength of Sandstone Based on Point Load

Renmin Zhujiang
In rock mechanics and engineering practice, accurate and rapid evaluation of uniaxial compressive strength and tensile strength of rock is important for engineering design and construction safety. Traditional test methods are time-consuming and laborious,
LIU Yongzhi, FANG Qingyao, ZHANG Kun, YAO Huayan, LIU Wu, LIU Guang   +5 more
doaj  

Elm Farm Research Centre: Sheepdrove Organic Farm (experimental farm) [PDF]

Sheepdrove Organic Farm – 800 ha downland organic farm in southern England. Mixed farm of arable, forage, beef, pigs and silvo-poultry. Office and meeting facilities.

core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Project Based-Learning (PjBL) as Pedagogical Framework and Poetry Learning Outcomes Among Indonesian Students: An Experimental Study

Educational Process: International Journal
Background/purpose. This study investigates the efficacy of Project-Based Learning (PjBL) as a pedagogical framework for teaching poetry in Indonesian elementary schools.
Mersty Elisabeth Rindengan , Risal Maykel Merentek   +1 more
doaj   +1 more source