Results 61 to 70 of about 5,472,250 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
BuildingsIn order to investigate the lateral working performance of large-scale steel casing-reinforced concrete pile composite members, this paper sets up large-scale steel casing-reinforced concrete pile composite members with different slenderness ratios λ ...
Duoyin Wang +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Leveraging experimental designs in tourism economics research
Experimental research represents a significant yet underutilized methodological approach in tourism economics, offering robust tools designed to uncover causal relationships and isolate independent variable effects. Traditional approaches tend to rely on
Souza-Neto, Valerio +3 more
core +1 more source
THE JOSEF REGIONAL UNDERGROUND RESEARCH CENTRE (JOSEF URC)
Rudarsko-geološko-naftni Zbornik, 2012 The Josef Gallery, located in the central Bohemia region of the Czech Republic was first excavated in 1981 as an exploration complex for the potential mining of gold.
Dana Pacovská +2 more
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Analytical and Experimental Study of Key Performance of Helicopter Rotor Torsion–Tension Straps
ActuatorsAs a crucial component of rotor systems, tension and torsion (TT) straps, recognized for their compact structure, have been adopted in advanced helicopters such as the SB > 1, EC145, and Mi-26.
Yamin Wang, Ruchuan Zhou, Wenjun Huang
doaj +1 more source
Research on transfering the dynamic process by the spring
Mokslas: Lietuvos Ateitis, 2010 The article describes the particulars of transferring the dynamic process applying the spring and explains the possibilities of diagnostics for support bearings insulated from the external body using resilient elements.
Vytautas Bučinskas, Jevgenij Dmitrijev
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source