Results 91 to 100 of about 8,711,360 (296)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Influence of Friction Forces and Gravity on the Quality of Movement in the MWR Rehabilitation Supporting Device

Applied Sciences
Recovering from upper limb injuries is very important because having limited functionality affects everyday tasks. Rehabilitation supporting systems significantly impact the results; however, it is important to ensure that they are safe and accurate ...
Bogusz Lewandowski
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Experimental Studies of Hadronization and Parton Propagation in the Space-Time Domain

, 2009
Over the past decade, new data have become available from DESY, Jefferson Lab, Fermilab, and RHIC that connect to parton propagation and hadron formation.
Accardi, Accardi, Airapetian, Airapetian, Airapetian, Akopov, Arleo, Baier, Bass, Brodsky, Brooks, Brooks, Del Duca, Dolejsi, Domdey, Falter, Gallmeister, Geesaman, H. Hakobyan, Johnson, Johnson, Kopeliovich, Kopeliovich, Kopeliovich, Majumder, Majumder, W.K. Brooks   +26 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Review of Experimental Investigations on Wells Turbines for Wave Energy Conversion

Energies
Wells turbines are one of the most attractive types of rotating machines installed in Oscillating Water Column (OWC) devices, owing to their simplicity of construction and reliability.
Fabio Licheri, Tiziano Ghisu, Francesco Cambuli, Pierpaolo Puddu, Mario Carta   +4 more
doaj   +1 more source

Experimental studies on the effects of nocturnal noise on cortisol awakening response

Noise and Health, 2010
Cortisol awakening response (CAR), a considerable increase in cortisol concentrations post-awakening, is considered a reliable indicator of the reactivity of the hypothalamus-pituitary-adrenal axis (HPA). As noise has been shown to activate the HPA-axis,
Barbara Griefahn, Sibylle Robens
doaj   +1 more source

Experimental studies with a mercury bombardment thrustor system [PDF]

Performance tests of mercury electron bombardment ion engine ...
Masek, T. D.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source