Results 51 to 60 of about 251,407 (198)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Experimental Study of the effect of closed cavity wall on buildings cooling loads saving

Journal of Engineering, 2015
The experimental study showed the use of closed cavity wall (the thickness of the cavity 5cm) made a percentage reduction in the cooling load caused by heat gain from the wall by (21.5 %) compared with the conventional wall.
Qussai Jihad Abdul Ghafour, Ass. Prof. Dr., Bashar Kamil Mahmoud   +1 more
doaj  

BRCA germline mutation test for all woman with ovarian cancer?

BMC Cancer, 2019
Background Delivering widespread BRCA testing to patients with ovarian cancer has been suggested by several scientists, recommended by professional societies and solicited by patients organizations.
A. V. Paradiso, M. Digennaro, M. Patruno, S. De Summa, S. Tommasi, I. Berindan-Neagoe   +5 more
doaj   +1 more source

Novel theory of mind task demonstrates representation of minds in mental state inference

Scientific Reports, 2022
Theory of mind (ToM), the ability to represent the mental states of oneself and others, is argued to be central to human social experience, and impairments in this ability are thought to underlie several psychiatric and developmental conditions.
Emily L. Long, Hélio Clemente Cuve, Jane Rebecca Conway, Caroline Catmur, Geoffrey Bird   +4 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase.

Journal of Lipid Research, 1994
In view of the suppressive effect of tumor necrosis factor alpha (TNF alpha) on lipoprotein lipase (LPL) and of the potential proatherogenic effects of these two macrophage secretory products, we have tested the possibility that LPL could modulate the ...
G Renier, E Skamene, J B DeSanctis, D Radzioch   +3 more
doaj  

HISTO-MORPHOLOGICAL STUDY OF FUNCTIONAL OVERLOAD (CLINICAL EXPERIMENTAL STUDY)

Romanian Journal of Oral Rehabilitation
Traumatic occlusion function is a continuous overload of dental system in chewing function which causes various damage in periodontal. This overload is visible not only in the full dental system, but also in the lack of teeth. Histo-morphological changes
Alketa Qafmolla, Doriana Agop Forna, Ruzhdie Qafmolla, Norina Consuela Forna   +3 more
doaj   +1 more source

Evaluation of Analgesic Activity of Extracts of Delphinium denudatum in Animal Models: A Dose-dependent Pre-clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Pain is a common symptom of majority of clinical disorders which brings patients to a physician. Many traditional medicines have been introduced for relieving the pain and one such herb, Delphinium denudatum, is claimed to have an ...
Imran Zaheer, Syed Ziaur Rahman, Rahat Ali Khan, Mehtab Parveen, Mushtaq Ahmad   +4 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source