Results 231 to 240 of about 12,685,705 (296)

Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation. [PDF]

Metabolomics
Fan HY, Hsieh CC, Chen TP, Lai PJ, Hsu HY, Yeh CL, Wu CW, Chien KL, Huang HY, Tung YT.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Identification and experimental validation of biomarkers associated with paraptosis in meningioma. [PDF]

Medicine (Baltimore)
Li H, Ding R, Zheng Y, Wang D, Deng T, Wu Z, Li L, Ma X, Cheng C, Zhang Y, Luo Y, Zhang H, Chen Y, Yu Y, Hou W, Ding T, Xie M, Bai X, Yang H, Wang Y, Zheng M.   +20 more
europepmc   +1 more source

Distributed Fiber-Optic Shape Sensing with Endpoint Error Compensation: Theory and Experimental Validation. [PDF]

Sensors (Basel)
Rossi L, Falcetelli F, Gagliardo F, Lovato P, Bastianini F, Di Sante R, Bolognini G.   +6 more
europepmc   +1 more source

Experimental Validation of a Battery-Free RFID-Powered Implantable Neural Sensor and Stimulator. [PDF]

Sensors (Basel)
Pedigoni Bulisani LE, Herculano MA, Pauris CC, do Prado LRB, Sakai LJ, Júnior FMP, Marchi E.   +6 more
europepmc   +1 more source

Mechanical Modeling and Experimental Validation of a Front-Push Orthopedic Brace: Compressive-Shear Force Characterization Under Controlled Misalignment. [PDF]

Bioengineering (Basel)
Zisi M, Ricci V, Rocchi A, Canali V.
europepmc   +1 more source