Sentara Healthcare: A Case Study Series on Disruptive Innovation Within Integrated Health Systems [PDF]
, 2011 Examines how integration and ties with health plans, physicians, and hospitals helped protect against revenue volatility and enabled experimentation; factors that facilitate integration; innovative practices; lessons learned; and policy ...
Rosie O'Donnell, Vineeta Vijayaraghavan
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Keeping Your Options Open [PDF]
In standard models of experimentation, the costs of project development consist of (i) the direct cost of running trials as well as (ii) the implicit opportunity cost of leaving alternative projects idle. Another natural type of experimentation cost, the
Jean Guillaume Forand
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Report on a medium-scale three dimensional artificial soundscape rendition: research and development system [PDF]
, 2002 A geodesic dome housing a 32Xspeaker
Lennox, Peter
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Lignées de projets, agir expérimental et fabrique urbaine : regard sur le « laboratoire grenoblois »
MétropolesIs urban experimentation merely an isolated, one-off act with no future, or is it part of a process that develops over time? If so, how should we name this process? How can it be analysed?
Charles Ambrosino
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Ethical budgets in (psycho-)linguistic fieldwork
LinguisticsAs most linguists and social scientists are now aware, cross-cultural field research can be extractive, especially when the target community does not have ready access to and/or understanding of the research products.
Sarvasy Hannah S.
doaj +1 more source