Results 181 to 190 of about 649,224 (361)

Historical Issues Concerning Animal Experimentation in the United States

, 1981
The use of animals for research and teaching has now become an issue of great concern in the United States. In contrast to the legislative systems in Britain, Scandinavia and many European countries, American scientists can pursue research projects with ...
Sechzer, Jeri A.
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

NPS Field Experimentation Program for Special Operations (FEPSO) TNT 13-3 Final Report [PDF]

, 2013
The NPS Field Experimentation Program was initiated in FY02 to Provide an opportunity for NPS faculty and students to evaluate New technologies from their research in a field environment.
Buettner, Raymond R., Meyer, Ramsey, Turley, Nelly, Oros, Carl   +3 more
core  

Double-Flush Riveting for Hybrid Busbar Assembly

Metals
This paper explores a novel double-flush riveting process for assembling hybrid busbars made from aluminum and copper sheets. The process involves drilling and forging countersunk holes with controlled geometry in both materials followed by compression ...
Rui F. V. Sampaio, João P. M. Pragana, Miguel P. Figueiredo, Ivo M. F. Bragança, Carlos M. A. Silva, Paulo A. F. Martins   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimentation in software engineering: an introduction

, 2000
C. Wohlin, P. Runeson, Martin Höst, Magnus C. Ohlsson, B. Regnell, Anders Wesslén   +5 more
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Télévision expérimentale et télévision expérimentée. Le « moment expérimental » revisité par le Service de la Recherche (RTF/ORTF) et sa préfiguration (1955-1965)

Mise au Point
One usually speaks of a medium’s “experimental moment” as opposed to its “institutional stabilization”, but experimentation can continue once institutionalization is in place.
Guillaume Soulez
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source