Results 231 to 240 of about 1,169,893 (336)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Integrating Kolb's experiential learning theory into nursing education: a four-stage intervention with case analysis, mind maps, reflective journals, and peer simulations for advanced health assessment. [PDF]

Front Med (Lausanne)
Cheng J, Wu Y, Huang L, Wu Y, Guan Y.
europepmc   +1 more source

Experimentation and Disappointment [PDF]

B. Luppi
core  

Forced Convection Experimentation Designed for Cooling Behaviors Encompassing Water Jet Impingement

, 2019
N. K. Kund
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evaluation of Occlusal Stains and Surface Roughness of Prefabricated Zirconia Crowns in Pediatric Dentistry: An Observational and <i>In Vitro</i> Study. [PDF]

Int J Clin Pediatr Dent
Bahammam HA, Rady AF.
europepmc   +1 more source

Apports de l'expérimentation dans l'étude de la réception en SIC: le cas des étiquettes de vin (Contributions of Experimentation on Studying Reception: The Case of Wine Labeling)

, 2013
Mihaela Bonescu, Diana Bratu, Émilie Ginon, Angela Sutan   +3 more
openalex   +1 more source

Drug Experimentation in Healthy Volunteers

, 2011
Giovanni Gori, Giuseppe Pasqualetti, C. L. Castiglioni, Corrado Blandizzi, Mario del   +4 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Living Labs as catalysts for experiential learning in law enforcement training: Insights from the TENACITy project. [PDF]

Open Res Eur
Margaros K, Aposkiti C.
europepmc   +1 more source