Results 41 to 50 of about 3,549,374 (192)

Editorial: Sports, economics, and natural experiments: advances and retrospection [PDF]

open access: yes
Sports provide a unique field laboratory for advancing behavioral microeconomics, offering precise and objective measurements of behavior due to standardized rules, clear observability, and highly motivated expert participants.
Gauriot, Romain   +2 more
core   +1 more source

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

open access: yes, 2020
Understanding how neuronal activation leads to specific behavioral output is fundamental for modern neuroscience. Combining optogenetics in rodents with behavioral testing in validated paradigms allows the measurement of behavioral consequences upon ...
Wallén-Mackenzie, Åsa   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

salehsedghpour/hydragen-experiments: Initial release

open access: yes, 2022
This release is mainly about getting the DOI from Zenodo. What's Changed Create LICENSE by @salehsedghpour in https://github.com/salehsedghpour/hydragen-experiments/pull/1 New Contributors @salehsedghpour made their first contribution in https ...
Mohammad Reza Saleh
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Thermal clustering of solid ethane with potential relevance to Charon’s Mordor region

open access: yesAstronomy & Astrophysics
The methane condensed in Charon’s winter hemisphere undergoes photolysis by interplanetary medium Lyman-α photons, which yields solid ethane as the dominant photoproduct.
Gimar C. J.   +4 more
doaj   +1 more source

Synthesis, morphological analysis, antibacterial activity of iron oxide nanoparticles and the cytotoxic effect on lung cancer cell line

open access: yesHeliyon, 2020
Focusing on the huge importance associated in developing functional materials, this research study describes the synthesis, characterization of morphology, bactericidal activity and cytotoxic effect of iron oxide nanoparticles (IONPs).
Subrata Das   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CAM-Delam assay to score metastatic properties by quantifying delamination and invasion capacity of cancer cells

open access: yes, 2022
The major cause of cancer-related deaths is metastasis formation (i.e., when cancer cells spread from the primary tumor to distant organs and form secondary tumors).
Gunhaga, Lena   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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