Results 71 to 80 of about 965,355 (303)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Guidelines for the management of the foot health problems associated with rheumatoid arthritis [PDF]

, 2011
Background. Rheumatoid arthritis (RA) as a chronic systemic disease, commonly affects the feet, impacting negatively on patients' quality of life. Specialist podiatrists have a prime role to play in the assessment and management of foot and ankle ...
Bowen, C, Dagg, A, Davies, S, Graham, A, Longrigg, K, Lyons, C, Williams, AE   +6 more
core   +1 more source

Managing Intoeing in Children [PDF]

, 2011
Intoeing can be accurately diagnosed using a history, physical examination, and torsional profile. (Strength of Recommendation [SOR]: C, based on expert consensus.) The three most common causes of intoeing (i.e., metatarsus adductus, internal tibial ...
Goodemote, Patricia, Henry, Susan L., Talley, William   +2 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Diabetic neuroosteoarthropathy: an interdisciplinary expert consensus

Сахарный диабет
OBJECTIVE. To analyze and describe existing methods for the diagnosis and treatment of diabetic neuroosteoarthropathy.MATERIALS AND METHODS. A search and analysis of clinical trials, meta-analyses, systematic reviews and clinical guidelines on the ...
V. B. Bregovskii, G. Y. Strakhova, S. A. Osnach, V. N. Khramilin, G. R. Galstyan, A. Y. Tokmakova, E. Y. Komelyagina, V. G. Protsko, A. L. Rybinskaya, A. K. Mursalov, G. P. Ivanov, I. A. Pakhomov, V. N. Obolenskii, E. P. Sorokin, V. V. Kuznetsov, S. I. Kireev, I. V. Gur'eva, V. A. Mitish, Y. S. Paskhalova, P. S. Bardyugov   +19 more
doaj   +1 more source

Optimizing the use of expert panel reference diagnoses in diagnostic studies of multidimensional syndromes [PDF]

, 2014
__Abstract__ Background: In the absence of a gold standard, a panel of experts can be invited to assign a reference diagnosis for use in research. Available literature offers limited guidance on assembling and working with an expert panel for this ...
Aalten, P. (Pauline), Bossuyt, P.M.M. (Patrick), Handels, R.L. (Ron), Joore, M.A. (Manuela), Leentjens, A.F. G. (Albert F. G.), Severens, J.L. (Hans), Verhey, F.R.J. (F. R J), Wolfs, C.A.G. (Claire)   +7 more
core   +1 more source

Management of achalasia cardia: Expert consensus statements [PDF]

Journal of Gastroenterology and Hepatology, 2018
AbstractAchalasia cardia (AC) is a frequently encountered motility disorder of the esophagus resulting from an irreversible degeneration of neurons. Treatment modalities are palliative in nature, and there is no curative treatment available for AC as of now. Significant advancements have been made in the management of AC over last decade.
Ramchandani, Mohan, Nageshwar Reddy, Duvvuru, Nabi, Zaheer, Chavan, Radhika, Bapaye, Amol, Bhatia, Shobna, Mehta, Nilay, Dhawan, Pankaj, Chaudhary, Adarsh, Ghoshal, Uday Chand, Philip, Mathew, Neuhaus, Horst, Devière, Jacques, Inoue, Haruhiro   +13 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The top five research priorities in physician-provided pre-hospital critical care: a consensus report from a European research collaboration [PDF]

, 2011
Background: Physician-manned emergency medical teams supplement other emergency medical services in some countries. These teams are often selectively deployed to patients who are considered likely to require critical care treatment in the pre-hospital ...
Espen Fevang, David Lockey, Julian Thompson, Hans Lossius, null null   +4 more
core   +2 more sources