Results 71 to 80 of about 1,295,929 (250)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Oregon Recycling Steering Committee process report

, 2020
prepared by: Oregon Consensus, National Policy Consensus Center, Portland State University.Title from PDF cover (viewed on November 4, 2020)."This report is respectfully submitted to DEQ by the Oregon Consensus Facilitation Team to conclude the Recycling

core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Expert consensus regarding drivers of antimicrobial stewardship in companion animal veterinary practice : a Delphi study [PDF]

, 2018
Antimicrobial resistance (AMR) is a global challenge facing both human and animal healthcare professionals; an effective response to this threat requires a 'One-Health' approach to antimicrobial stewardship (AMS) to preserve important antibiotics for ...
Smith, Matt, Nuttall, Tim, Flowers, Paul, King, Caroline, Currie, Kay   +4 more
core   +1 more source

Diabetic neuroosteoarthropathy: an interdisciplinary expert consensus

Сахарный диабет
OBJECTIVE. To analyze and describe existing methods for the diagnosis and treatment of diabetic neuroosteoarthropathy.MATERIALS AND METHODS. A search and analysis of clinical trials, meta-analyses, systematic reviews and clinical guidelines on the ...
V. B. Bregovskii, G. Y. Strakhova, S. A. Osnach, V. N. Khramilin, G. R. Galstyan, A. Y. Tokmakova, E. Y. Komelyagina, V. G. Protsko, A. L. Rybinskaya, A. K. Mursalov, G. P. Ivanov, I. A. Pakhomov, V. N. Obolenskii, E. P. Sorokin, V. V. Kuznetsov, S. I. Kireev, I. V. Gur'eva, V. A. Mitish, Y. S. Paskhalova, P. S. Bardyugov   +19 more
doaj   +1 more source

Expert consensus on vitamin D in osteoporosis

Annals of Joint
Adequate vitamin D is essential for maintaining optimal bone health, preventing and treating of osteoporosis. However, in recent years, large clinical trials and meta-analyses on the efficacy of vitamin D supplementation to prevent fractures in populations at different risks have been equivocal.
Lei, S., Zhang, X., Song, L., Wen, J., Zhang, Z., Tian, J., Yang, R., Xu, S., Qiu, S., MacIsaac, R.J., Mac-Way, F., Dupuis, M.È., Benaiges, David, Mauricio Puente, Dídac, Sommer, A.P., Barzilay, J.I., Gallagher, J.C., Pan, L., Ji, L., Fang, P., Li, Yuda, Liu, Q., Zhao, J., Xue, Y., Shen, Y., Wang, L., Han, J., Liu, G., Universitat Autònoma de Barcelona   +28 more
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Partially hydrolyzed formula in non-exclusively breastfed infants: A systematic review and expert consensus

, 2019
Objectives: Guidance and evidence supporting routine use of partially hydrolyzed formula (pHF) versus intact cows’ milk protein (CMP) formula are limited in non-exclusively breastfed infants. The aim of this review was to better clarify issues of routine
David M. Fleischer, Amir Hamzah Abdul Latiff, Peter K. Smith, Greenhawt, Matthew J, Smith, Peter K, Vandenplas, Yvan, Pedro Gutiérrez-Castrellón, Andrea von Berg, Gutierrez-Castrellon, Pedro, Yvan Vandenplas, Fleischer, David M, von Berg, Andrea, Mohamad-Iqbal S. Miqdady, Miqdady, Mohamad-Iqbal S, Matthew J. Greenhawt, Latiff, Amir Hamzah Abdul   +15 more
core   +1 more source