Results 81 to 90 of about 267,482 (302)

Diabetic neuroosteoarthropathy: an interdisciplinary expert consensus

Сахарный диабет
OBJECTIVE. To analyze and describe existing methods for the diagnosis and treatment of diabetic neuroosteoarthropathy.MATERIALS AND METHODS. A search and analysis of clinical trials, meta-analyses, systematic reviews and clinical guidelines on the ...
V. B. Bregovskii, G. Y. Strakhova, S. A. Osnach, V. N. Khramilin, G. R. Galstyan, A. Y. Tokmakova, E. Y. Komelyagina, V. G. Protsko, A. L. Rybinskaya, A. K. Mursalov, G. P. Ivanov, I. A. Pakhomov, V. N. Obolenskii, E. P. Sorokin, V. V. Kuznetsov, S. I. Kireev, I. V. Gur'eva, V. A. Mitish, Y. S. Paskhalova, P. S. Bardyugov   +19 more
doaj   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Evidence-based public health messaging on the non-visual effects of ocular light exposure: a modified Delphi expert consensus [PDF]

Introduction In addition to vision, light regulates circadian rhythms, sleep, mood and alertness. Despite growing scientific understanding, there remains a gap in translating this knowledge into accessible, evidence-based guidance. The goal of this paper
Fernandez-Alonso, Maydel, Price, Luke, Weiskopf, Daniela, Joyce, Daniel S., Denneman, Jan, Rabstein, Sylvia, Spitschan, Manuel, Lok, Renske, Zauner, Johannes, Veitch, Jennifer A, Stefani, Oliver, Wright, Kenneth, Kervezee, Laura, McGlashan, Elise M., Brainard, George C., Schlangen, Luc, Sliney, David H., Brown, Timothy, Blume, Christine, Broszio, Kai, Lucas, Robert, Higuch, Shigekazu, Najjar, Raymond P., van Duijnhoven, Juliëtte, Gordijn, Marijke   +24 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

‘There is only one thing that is truly important in an IVF laboratory: everything’ Cairo Consensus Guidelines on IVF Culture Conditions [PDF]

, 2019
This proceedings report presents the outcomes from an international expert meeting to establish consensus guidelines on IVF culture conditions. Topics reviewed and discussed were: embryo culture – basic principles and interactions; temperature in the IVF
Consensus Group, Cairo, Cairo Consensus Group   +1 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Behavioural Signs of Pain in Cats: An Expert Consensus

PLOS ONE, 2016
To identify where a consensus can be reached between veterinary experts in feline medicine on the core signs sufficient for pain (sufficient to indicate pain when they occur, but not necessarily present in all painful conditions) and necessary for pain (necessary in the presence of pain, but not always indicative of pain).A modified Delphi technique ...
Isabella Merola, Daniel Mills
openaire   +5 more sources