Results 171 to 180 of about 2,172,368 (301)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Biparametric Versus Multiparametric MRI for VI-RADS Assessment: Reproducibility Relative to Routine mpMRI Reporting and Impact of Radiologist Experience in a Single-Center Study. [PDF]

Cancers (Basel)
Urraro F, Giordano N, Patanè V, Brunese MC, Rossi C, Cioffi A, Russo A, Varelli C, Cappabianca F, Reginelli A.   +9 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Response to Comments on “Artificial Intelligence-Driven Drafting of Chest X-Ray Reports: 2025 Position Statement From the Korean Society of Thoracic Radiology Based on an Expert Survey” [PDF]

Korean J Radiol
Jeong W, Hwang E, Jin G.
europepmc   +2 more sources

Enhancing a job exposure matrix with subject-specific information to assess combined exposure to benzene, toluene, and xylene in a case-control study. [PDF]

Ann Work Expo Health
Friesen MC, Xie S, Locke SJ, Baris D, Schwenn M, Rothman N, Johnson A, Karagas MR, Koutros S, Silverman DT.   +9 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Summary of best evidence for targeted body temperature management in patients with severe neurological illness. [PDF]

Front Med (Lausanne)
Zhang D, Li F, Wen D, Zeng Z, Yan F, He H, Yang X.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Large Language Model-Driven Analysis and Report Generation of Endoscopy Videos-A Pilot Study. [PDF]

Dig Endosc
Massimi D, Stefano LD, Rizkala T, Spadaccini M, Mori Y, Menini M, Antonelli G, Khalaf K, Bisschops R, von Renteln D, Sharma P, Rex DK, Bretthauer M, Castoro C, LLM Working Group, Repici A, Hassan C.   +16 more
europepmc   +1 more source