Results 101 to 110 of about 23,690,640 (370)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

An expert system for mitigation actions

open access: yes2017 20th Conference of Open Innovations Association (FRUCT), 2017
This paper describes an approach, based on ontologies and expert system technology, for assisting the mitigation of advanced persistent threat (APT) attacks against critical infrastructures. We describe the approach, and a prototype expert system based on it.
Karanta, Ilkka, Rautila, Mika
openaire   +6 more sources

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

open access: yesMolecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien   +7 more
wiley   +1 more source

An Expert is Worth One Token: Synergizing Multiple Expert LLMs as Generalist via Expert Token Routing [PDF]

open access: yesarXiv
We present Expert-Token-Routing, a unified generalist framework that facilitates seamless integration of multiple expert LLMs. Our framework represents expert LLMs as special expert tokens within the vocabulary of a meta LLM. The meta LLM can route to an expert LLM like generating new tokens. Expert-Token-Routing not only supports learning the implicit
arxiv  

Expert system rheometry

open access: yesMaterials Today, 2009
Inks, drilling fluids, shower gels and drug delivery vehicles are just a few examples of the many industrial and consumer products based on colloidal and nanostructured complex fluids. The successful formulation of these materials is promoted by understanding how rheological behaviour, which typically dictates performance, relates to underlying ...
S.P. Carrington, Samiul Amin
openaire   +2 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Design of an emergency medical information system for mass gatherings

open access: yesHeliyon
Background: The frequency of mass gatherings is increasing. Such events often involve many people and carry the risk of mass casualty incidents, which require substantial medical resources from various healthcare institutions. The current medical system,
Yu Tian   +6 more
doaj  

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

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