Results 111 to 120 of about 614,844 (218)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Evaluation of Novel Co-Processed Excipients for Direct Compression Using the Sediment Delivery Model (SeDeM) Expert System. [PDF]

Pharmaceuticals (Basel)
Ciurba A, Antonoaea P, Rédai EM, Pintea A, Pintea C, Cojocariu AA, Bîrsan M, Mihalcea MF, Vlad RA.   +8 more
europepmc   +1 more source

Proposal of neural network model for neurocognitive rehabilitation and its comparison with fuzzy expert system model. [PDF]

BMC Med Inform Decis Mak, 2023
Kotyrba M, Habiballa H, Volna E, Jarusek R, Smolka P, Prasek M, Malina M, Jaremova V.   +7 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

KRASAVA-An Expert System for Virtual Screening of KRAS G12D Inhibitors. [PDF]

Int J Mol Sci
Tinkov OV, Gurevich PE, Nikolenko SA, Kadyrov SD, Bogatyreva NS, Grigorev VY, Ivankov DN, Pak MA.   +7 more
europepmc   +1 more source

Accurate Prediction of Anxiety Levels in Asian Countries Using a Fuzzy Expert System. [PDF]

Healthcare (Basel), 2023
Ramzan M, Hamid M, Alhussan AA, AlEisa HN, Abdallah HA.   +4 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

QbD-Based Design Space Development for Honey-Containing Traditional Chinese Medicine Tablets Assisted by the SeDeM Expert System and Machine Learning. [PDF]

Pharmaceutics
Deng X, Mu D, Song F, Miao Y, Yin Q, Yin H.   +5 more
europepmc   +1 more source

Initial study on an expert system for spine diseases screening using inertial measurement unit. [PDF]

Sci Rep, 2023
Pelc M, Vilimkova Kahankova R, Blaszczyszyn M, Mikolajewski D, Konieczny M, Khoma V, Bara G, Zygarlicki J, Martinek R, Gupta MK, Gorzelanczyk EJ, Pawłowski M, Czapiga B, Zygarlicka M, Kawala-Sterniuk A.   +14 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source