Results 131 to 140 of about 696,114 (317)

Expert Systems - A Natural History [PDF]

open access: yes, 1989
This paper examines the origins, current state and future prospects for expert systems. The origins are traced from the schism with classic Artificial Intelligence. The characteristics of early expert systems are described and contrasted with more recent
Shadbolt, N. R.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Intelligent query agent for structural document databases [PDF]

open access: yes, 2009
[[abstract]]Querying a database for document retrieval is often a process close to querying an answering expert system. In this work, we apply the expert system techniques to the intelligent query agent establishment and regard the structural document ...
Mon-Fong Jiang ; S. S. Tseng; Chung-Jiun Tsai
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

An intelligent questionnaire analysis expert system [PDF]

open access: yes, 2010
[[abstract]]In the questionnaire analysis, how to find a statistically significant difference between two or more groups in a continuous measure is one of the major problems in researches.
Chu, Yian-Shu; Tseng, Shian-Shyong ; Tsai, Yu-Jie; Luo, Ren-Jei
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

A novel CLIPS-based medical expert system for migraine diagnosis and treatment recommendation

open access: yesKuwait Journal of Science
Migraines are classified as a neurological disorder defined by recurrent headaches with pain that ranges from mild to severe. Currently, this disorder lacks a permanent cure and definitive diagnostic test.
doaj   +1 more source

Survey of Health Literacy of People Referred to the Libraries of Public Libraries Foundation

open access: yesمدیریت اطلاعات سلامت, 2017
about person’s health. The purpose of this study was to determine the level of literacy among 18-50-year old people that referred to the public libraries of Kerman, Iran. Methods: Sample size determined 375 people using clustering method.
Masomeh Ansari   +3 more
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

MYOCARDIAL INFARCTION DIAGNOSIS USING FUZZY-EXPERT APPROACH

open access: yesJournal of ICT, 2004
A fuzzy expert system is a system which incorporates fuzzy sets and/or fuzzy logic into its reasoning process and/ or knowledge representation scheme.
Fadzilah Siraj, Rafikha Aliana A. Raof
doaj  

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