Results 141 to 150 of about 696,114 (317)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Can a computer expert system aid the process of clinical decision-making in podiatry? [PDF]
The aim of this research was to invetigate the clinical decision-making processes used in podiatry and hence to investigate if a computer expert system could be used to aid the process of clinical decision-making.
Curran, Mike
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
System and method for specifying an expert system [PDF]
, 1992 A method and system are provided for specifying an expert system. Multiple task specifications are formed for specifying tasks as functional units of the expert system.
Yen, Chia H., Lee, Jonathan Y.
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
An expert system for material handling equipment selection [PDF]
Manufacturing Systems are subject to increasingly frequent changes in demand in terms of number and type of products they produce. It is impractical to continually reconfigure the facilities, but it is possible to modify the material handling ...
Al-Meshaiei, Eisa Abdullah Eisa S.
core
AN EXPERT SYSTEM ON NUMERICAL CONTROL AUTOMATIC PROGRAMMING [PDF]
, 1991 This paper introduces briefly an expert system on numerical control automatic programing (NCAPES) including knowledge representation, blackboard architecture with different levels, problem solving strategy, forward reasoning and interpreter.
Song GN(宋国宁) +3 more
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A Sustainability-Based Expert System for Additive Manufacturing and CNC Machining. [PDF]
Sensors (Basel), 2023 Perera JC +4 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source