Results 61 to 70 of about 351,291 (241)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Knowledge Engineering in Chemistry: From Expert Systems to Agents of Creation. [PDF]

Acc Chem Res, 2023
Kondinski A, Bai J, Mosbach S, Akroyd J, Kraft M.   +4 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

“I don’t let anybody die on my watch”: perspectives on the intersection of community overdose response and emergency medical services among people who use drugs in Seattle, WA

Harm Reduction Journal
Background The increasing implementation of harm reduction strategies such as take-home naloxone has placed people who use drugs (PWUD) in the position of overdose responders during overdose events, but the perspectives of PWUD are underrepresented in ...
Courteney Wettemann, David L. Perlmutter, Tessa Frohe, Taylor Ryan, Grover “Will” Williams, Nathan Holland, Rachel Rourke, Robert Pitcher, Callan Elswick Fockele, Brenda Goh, Germaine Billingsley, Jenna van Draanen   +11 more
doaj   +1 more source

A Review of Computer-Aided Expert Systems for Breast Cancer Diagnosis. [PDF]

Cancers (Basel), 2021
Liew XY, Hameed N, Clos J.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Applying Machine Learning of Erythrocytes Dynamic Antigens Store in Medicine

Frontiers in Molecular Biosciences, 2019
Erythrocytes Dynamic Antigens Store (EDAS) is a new discovery. EDAS consists of self-antigens and foreign (non-self) antigens. In patients with infectious diseases or malignancies, antigens of infection microorganism or malignant tumor exist in EDAS ...
Mahmoud Rafea, Passant Elkafrawy, Mohammed M. Nasef, Rasha Elnemr, Amani Tariq Jamal   +4 more
doaj   +1 more source

Expert Systems for Predicting the Bioavailability of Sun Filters in Cosmetic Products, Software vs. Expert Formulator: The Benzophenone-3 Case. [PDF]

Pharmaceutics, 2022
Baldisserotto A, Baldini E, Ravarotto S, Cesa E, De Lucia D, Durini E, Vertuani S, Manfredini S, Michniak-Kohn BB.   +8 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Short course hypofractionated whole breast irradiation after conservative surgery: a single institution phase II study

Journal of Experimental & Clinical Cancer Research, 2017
Background To assess the oncologic outcomes of hypofractionated whole breast irradiation (Hypo-WBI). Methods Eligible patients had undergone breast conservative surgery for early breast cancer (pTis-2) and none/limited nodal involvement.
Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, Giuseppe Iaccarino, Valeria Landoni, Diana Giannarelli, Patrizia Vici, Lidia Strigari, Giuseppe Sanguineti   +9 more
doaj   +1 more source