Results 91 to 100 of about 19,865 (257)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Knowledge of legal professionals about age trends in false memory propensity: a vignette study

open access: yesScientific Reports
Professionals who evaluate witness testimony must understand the developmental factors that can affect statements credibility. This online vignette study investigated in how far 102 legal professionals (e.g., judges, attorneys, and police officers) were ...
Sanne T. L. Houben   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

You Understand, So I Understand: How a “Community of Knowledge” Shapes Trust and Credibility in Expert Testimony Evidence

open access: yesBehavioral Sciences
Sloman and Rabb found support for the existence of the community of knowledge (CK) effect, which occurs when individuals are more likely to report understanding and being able to explain even fake scientific information when told that an expert ...
Ashley C. T. Jones, Morgan R. Haga
doaj   +1 more source

The Code as Expert Witness

open access: yesAMA Journal of Ethics, 2001
The AMA's Code of Medical Ethics has been increasingly cited in judicial rulings concerning the medical profession, underscoring its evolution over its 154 years as the recognized authority on all aspects of professional behavior in the medical setting. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +3 more sources

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

INTERACTION BETWEEN ENVIRONMENTAL FORENSIC EXPERT WITNESS AND COURT DURING CRIMINAL PROCEEDINGS

open access: yesТеория и практика судебной экспертизы, 2014
The paper addresses the aspects of interaction between forensic witness experts and courts in the appointment and production of environmental forensic examinations during criminal proceedings.
E. Mayorova, N. Goncharuk, E. Adamova
doaj  

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