Results 71 to 80 of about 19,865 (257)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

SOME ASPECTS OF PROOF BY MEANS OF THE EXPERT STATEMENT

open access: yesХабаршы. Заң сериясы, 2019
This article considers the problems arising at assessment of expert statements. The actual data important for the correct solution of criminal case is determined by testimonies of the suspect, victim, witness, witness having right for protection, the ...
Tapalova R.B.   +2 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

LA IMPARCIALIDAD DEL DICTAMEN PERICIAL COMO ELEMENTO DEL DEBIDO PROCESO FAIRNESS OF THE EXPERT OPINION AS AN ELEMENT OF DUE PROCESS

open access: yesRevista Chilena de Derecho, 2011
El presente comentario tiene por objeto revisar la figura del perito y la objetividad e imparcialidad que deben regir los dictámenes que emita, con la finalidad de colaborar con el órgano jurisdiccional en la búsqueda de la verdad acerca de los hechos ...
Maite Aguirrezabal Grünstein
doaj  

"Fair" Mathematics in Assessing Delictual Damages [PDF]

open access: yesPotchefstroom Electronic Law Journal, 2011
In assessing delictual damages the plaintiff is burdened with the duty to prove loss with a preponderance of probability, including uncertain future loss. In quantifying such a claim an actuary is often used to make actuarial calculations based on proven
L Steynberg
doaj  

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