Results 101 to 110 of about 2,699,909 (326)

Legitimacy and Expertise in Global Internet Governance [PDF]

, 2015
Over the course of the past decade or so, attention among Internet policymakers and scholars has shifted gradually from substantive design principles to the structure of Internet governance.
Sylvain, Olivier
core   +1 more source

Hypermedia learning and prior knowledge: Domain expertise vs. system expertise [PDF]

, 2005
Prior knowledge is often argued to be an important determinant in hypermedia learning, and may be thought of as including two important elements: domain expertise and system expertise. However, there has been a lack of research considering these issues
Ajzen, Alexander, Barua, Beishuizen, Calisir, Chen, Chen, Chen, Chen, Chen, Crook, De Jong, Farrell, Fidel, Fitzgerald, Ford, Ford, Gerdes, Ghinea, Hill, Holscher, Hsu, Jonassen, Khalifa, Kim, Large, Last, Lawless, Lazonder, Lazonder, Lewis, Liaw, Littlejohn, Marchionini, McDonald, McDonald, Mohageg, Ng, Nielsen, Nilsson, Patel, Pazzani, Reed, Schumacher, Shapiro, Shin, Simmons, Spiro, Spyridakis, Torkzadeh, Torkzadeh, Vassileva   +51 more
core   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Secondhand smoke exposure in public outdoor spaces in the Netherlands: The stronger the smell, the more exposure to nicotine

Tobacco Induced Diseases
Introduction While secondhand smoke exposure in outdoor spaces has been investigated before, no data on outdoor secondhand smoke exposure have been collected in the Netherlands. Such data could help policymakers gain support for smoke-free outdoor public
Jeroen Bommelé, Hans Cremers, Wouter Den Hollander, Sigrid Troelstra, Gemma Geuke, Wiebe Dam, Eefje Willemse, Petra Hopman, Bethany Hipple Walters, Marc Willemsen   +9 more
doaj   +1 more source

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source

In Vitro Evaluation of the Effects of Plant-Based Protein Digestates on the Biology and Metabolism of Human Preadipocytes and Adipocytes

Proceedings
Background and Objectives: Excessive deposits of white adipose tissue lead to obesity. Preadipocyte differentiation, adipocyte metabolism, and some inflammatory and profibrotic factors are key in modulating early fat mass expansion and chronic low-grade ...
Catherine Lefranc-Millot, Caroline Perreau, Marion Bourdens, Noémie Juin, Mayoura Keophiphath   +4 more
doaj   +1 more source

Naturalism and Moral Expertise in the Zhuangzi [PDF]

, 2017
This essay will examine scholarly attempts at distilling a proto-ethical philosophy from the Daoist classic known as the Zhuangzi. In opposition to interpretations of the text which characterize it as amoralistic, I will identify elements of a natural ...
Kirby, Christopher
core   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source