Results 101 to 110 of about 60,361 (257)

Guidance for Interactive Visual Analysis in Multivariate Time Series Preprocessing

Sensors
Multivariate time series analysis presents significant challenges due to its dynamism, heterogeneity, and scalability. Given this, preprocessing is considered a crucial step to ensure analytical quality.
Flor de Luz Palomino Valdivia, Herwin Alayn Huillcen Baca   +1 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Who moved my scan? Early adopter experiences with pre- and post-market healthcare AI regulation challenges

Frontiers in Medicine
Real-world clinical experience provides a much-needed opportunity for deep learning AI algorithms to evolve and improve. Yet, it also constitutes a regulatory challenge, since such potential for learning may essentially change the algorithm and introduce
Aviad Raz, Yael Inbar, Netta Avnoon, Liat Bela Lifshitz-Milwidsky, Barkan Hofman, Asaf Honig, Ziv Paz   +6 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Using vision transformers for electrographic seizure classification to aid physician review of intracranial electroencephalography recordings

Frontiers in Human Neuroscience
We introduce a vision transformer (ViT)-based approach for automated electrographic seizure classification using time-frequency spectrogram representations of intracranial EEG (iEEG) recordings collected from patients implanted with the NeuroPace® RNS ...
Muhammad Furqan Afzal, Sharanya A. Desai, Wade Barry, Thomas K. Tcheng, Jonathan Kuo, Shawna W. Benard, Christopher B. Traner, David Greene, Cairn G. Seale, Martha J. Morrell   +9 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Exploring Factors Involved in Loan Approval Decision: Deep Insights and Data Analytics Techniques

IEEE Access
Accurate yet transparent credit-risk models are essential for responsible lending in the face of tightening global AI regulations. We propose an end-to-end, reproducible pipeline for loan-default prediction that integrates a three-way consensus feature ...
Xincai Li, Jiayu Li
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

IEM explained

Philosophical Psychology
In this paper I compare my account of IEM to another one, the Simple View, according to which a judgment is IEM just in case its grounds do not include an identity. The Simple View does not say why no identity assumption is needed to ground the singular judgment in the IEM cases; my account is meant to complement it by providing an answer to that ...
openaire   +2 more sources