Results 101 to 110 of about 220,602 (307)

Novel Actionable Counterfactual Explanations for Intrusion Detection Using Diffusion Models

Journal of Cybersecurity and Privacy
Modern network intrusion detection systems (NIDSs) rely on complex deep learning models. However, the “black-box” nature of deep learning methods hinders transparency and trust in predictions, preventing the timely implementation of countermeasures ...
Vinura Galwaduge, Jagath Samarabandu
doaj   +1 more source

Explaining Discrimination

Experiments on ethnic or racial discrimination often use names to signal originin market situations under the assumption that non-ethnic name signals do notsystematically affect the outcome. Using survey data, we demonstrate significantvariation in perceived trustworthiness and professionalism of names within origins.Linking this to a large-scale name ...
Billie Martiniello, Daniel Auer, Didier Ruedin   +2 more
openaire   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Guidance for Interactive Visual Analysis in Multivariate Time Series Preprocessing

Sensors
Multivariate time series analysis presents significant challenges due to its dynamism, heterogeneity, and scalability. Given this, preprocessing is considered a crucial step to ensure analytical quality.
Flor de Luz Palomino Valdivia, Herwin Alayn Huillcen Baca   +1 more
doaj   +1 more source

Explaining Recruitment to Extremism: A Bayesian Contaminated Case Control Approach [PDF]

, 2021
Roberto Cerina, Christopher Barrie, Neil Ketchley, Aaron Y. Zelin   +3 more
openalex  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Who moved my scan? Early adopter experiences with pre- and post-market healthcare AI regulation challenges

Frontiers in Medicine
Real-world clinical experience provides a much-needed opportunity for deep learning AI algorithms to evolve and improve. Yet, it also constitutes a regulatory challenge, since such potential for learning may essentially change the algorithm and introduce
Aviad Raz, Yael Inbar, Netta Avnoon, Liat Bela Lifshitz-Milwidsky, Barkan Hofman, Asaf Honig, Ziv Paz   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Using vision transformers for electrographic seizure classification to aid physician review of intracranial electroencephalography recordings

Frontiers in Human Neuroscience
We introduce a vision transformer (ViT)-based approach for automated electrographic seizure classification using time-frequency spectrogram representations of intracranial EEG (iEEG) recordings collected from patients implanted with the NeuroPace® RNS ...
Muhammad Furqan Afzal, Sharanya A. Desai, Wade Barry, Thomas K. Tcheng, Jonathan Kuo, Shawna W. Benard, Christopher B. Traner, David Greene, Cairn G. Seale, Martha J. Morrell   +9 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source