Results 81 to 90 of about 64,893 (276)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
IEEE AccessBean rust and angular leaf spot pose significant challenges to bean cultivation, impacting yields. Prompt disease identification maximizes productivity, but traditional methods need specialized expertise.
R. Karthik +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
AutomatikaThis paper presents a novel approach for identifying system topology and detecting causal relationships between servers in Air Traffic Control systems (ATC) by utilizing unstructured, raw communication logs.
Agneza Krajna +3 more
doaj +1 more source
SAFE PERIODS BOTH EXPLAIN AND NEED EXPLAINING [PDF]
Journal of the Experimental Analysis of Behavior, 2001 Dinsmoor's (2001) stress on the response‐produced safe period as a reinforcer for avoidance behavior is a positive contribution, even though several questions about such safe periods remain to be answered.
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Applied SciencesIn the context of autonomous driving, predicting pedestrian behavior is a critical component for enhancing road safety. Currently, the focus of such predictions extends beyond accuracy and reliability, placing increasing emphasis on the explainability ...
Angie Nataly Melo Castillo +2 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Frontiers in Digital HealthIntegrating multi-modal patient data to support personalized medicine has gained a lot of interest across different health domains over the past decade. Addressing this challenge requires the development and implementation of an informed, evidence-based ...
Emilia Daghir-Wojtkowiak +96 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source