Results 61 to 70 of about 64,893 (276)

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Explainability of a Machine Learning Granting Scoring Model in Peer-to-Peer Lending

IEEE Access, 2020
Peer-to-peer (P2P) lending demands effective and explainable credit risk models. Typical machine learning algorithms offer high prediction performance, but most of them lack explanatory power.
Miller Janny Ariza-Garzon, Javier Arroyo, Antonio Caparrini, Maria-Jesus Segovia-Vargas   +3 more
doaj   +1 more source

Explaining visual counterfactual explainers

, 2023
Altres ajuts: this work was supported by the Generalitat de Catalunya under the Industrial Doctorate Program (grant number 2020DI62).
Velazquez Dorta, Diego Alejandro, Rodríguez López, Pau, Lacoste, Alexandre, Laradji, Issam H., Roca i Marvà, Francesc Xavier, Gonzàlez, Jordi   +5 more
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Verifying Machine Learning Interpretability and Explainability Requirements Through Provenance

Software
Machine learning (ML) engineering increasingly incorporates principles from software and requirements engineering to improve development rigor; however, key non-functional requirements (NFRs) such as interpretability and explainability remain difficult ...
Lynn Vonderhaar, Juan Couder, Tyler Thomas Procko, Eva Lueddeke, Daryela Cisneros, Omar Ochoa   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

TravelRAG: A Tourist Attraction Retrieval Framework Based on Multi-Layer Knowledge Graph

ISPRS International Journal of Geo-Information
A novel framework called TravelRAG is introduced in this paper, which is built upon a large language model (LLM) and integrates Retrieval-Augmented Generation (RAG) with knowledge graphs to create a retrieval system framework designed for the tourism ...
Sihan Song, Chuncheng Yang, Li Xu, Haibin Shang, Zhuo Li, Yinghui Chang   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Prediction and explainability in AI: Striking a new balance?

Big Data & Society
The debate regarding prediction and explainability in artificial intelligence (AI) centers around the trade-off between achieving high-performance accurate models and the ability to understand and interpret the decisionmaking process of those models.
Aviad Raz, Bert Heinrichs, Netta Avnoon, Gil Eyal, Yael Inbar   +4 more
doaj   +1 more source