Results 51 to 60 of about 64,893 (276)

Improving disease classification performance and explainability of deep learning models in radiology with heatmap generators

Frontiers in Radiology, 2022
As deep learning is widely used in the radiology field, the explainability of Artificial Intelligence (AI) models is becoming increasingly essential to gain clinicians’ trust when using the models for diagnosis.
Akino Watanabe, Sara Ketabi, Sara Ketabi, Khashayar Namdar, Khashayar Namdar, Khashayar Namdar, Farzad Khalvati, Farzad Khalvati, Farzad Khalvati, Farzad Khalvati, Farzad Khalvati, Farzad Khalvati   +11 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Explainability-driven adversarial robustness assessment for generalized deepfake detectors

EURASIP Journal on Information Security
The capabilities of generative models to produce high-quality fake images require deepfake detectors to be accurate and have strong generalization performance.
Lorenzo Cirillo, Andrea Gervasio, Irene Amerini   +2 more
doaj   +1 more source

Toward Explainable Facial Expression Recognition Using Face Action Units: XFER-AU

IEEE Access
Face expression recognition (FER) has been extensively explored by the research community, with comparisons between different FER models typically relying on accuracy metrics.
Tanmay Tulsidas Verlekar, Arnav Goyal, Paulo Lobato Correia   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Pre Hoc and Co Hoc Explainability: Frameworks for Integrating Interpretability into Machine Learning Training for Enhanced Transparency and Performance

Applied Sciences
Post hoc explanations for black-box machine learning models have been criticized for potentially inaccurate surrogate models and computational burden at prediction time.
Cagla Acun, Olfa Nasraoui
doaj   +1 more source

On the Logical Design of a Prototypical Data Lake System for Biological Resources

Frontiers in Bioengineering and Biotechnology, 2020
Biological resources are multifarious encompassing organisms, genetic materials, populations, or any other biotic components of ecosystems, and fine-grained data management and processing of these diverse types of resources proposes a tremendous ...
Haoyang Che, Yucong Duan
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source