Results 101 to 110 of about 36,247 (313)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Multi-branch GAT-GRU-transformer for explainable EEG-based finger motor imagery classification

Frontiers in Human Neuroscience
Electroencephalography (EEG) provides a non-invasive and real-time approach to decoding motor imagery (MI) tasks, such as finger movements, offering significant potential for brain-computer interface (BCI) applications. However, due to the complex, noisy,
Zhuozheng Wang, Yunlong Wang
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A note on certain implications of clinical artificial intelligences for the field of medico-legal semiotics

Comparative Legilinguistics
Artificial intelligence has profound implications for the filed of clinical practices, and also for semiotics and law. In this article, we articulate and explain the different types of Clinical artificial intelligence (CAIs) as their normativity often ...
CAROLE SENECHAL, Nicholas Léger-Riopel
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

AI Explainability: Embedding Conceptual Models

, 2022
Artificial intelligence, especially based on machine learning, is rapidly transforming business operations and entire industries. However, as many complex machine learning models are considered to be black boxes, both adoption and further reliance on ...
Maass, Wolfgang, Castellanos, Arturo, Tremblay, Monica, Storey, Veda C., Lukyanenko, Roman   +4 more
core  

Transparent Task Delegation in Multi-Agent Systems Using the QuAD-V Framework

Applied Sciences
Task delegation in multi-agent systems (MASs) is crucial for ensuring efficient collaboration among agents with different capabilities and skills. Traditional delegation models rely on social mechanisms such as trust and reputation to evaluate potential ...
Jeferson José Baqueta, Mariela Morveli-Espinoza, Cesar Augusto Tacla   +2 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

HyCoViT: Hybrid Convolution Vision Transformer With Dynamic Dropout for Enhanced Medical Chest X-Ray Classification

IEEE Access
Medical chest X-ray (CXR) classification necessitates balancing detailed local feature extraction with capturing broader, long-range dependencies, especially when working with limited and heterogeneous datasets.
Omid Almasi Naghash, Nam Ling, Xiang Li
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source