Results 121 to 130 of about 220,602 (307)

Correlation study between serum uric acid level and cognitive impairment in middle-aged and elderly patients with hypertension: based on an explainable predictive model

Frontiers in Neurology
BackgroundPatients with primary hypertension are always comorbid with hyperuricemia. Serum uric acid exhibits a dual role in cognitive function.
Jiarui Wang, Jiarui Wang, Hetong Liao, Hetong Liao, Ping Zheng, Qinfen Chen, Dongxu Lu, Yihong Huang, Di Wu, Jiajia Hu, Juan Du, Xiaoyun Zhang   +11 more
doaj   +1 more source

IEM explained

Philosophical Psychology
In this paper I compare my account of IEM to another one, the Simple View, according to which a judgment is IEM just in case its grounds do not include an identity. The Simple View does not say why no identity assumption is needed to ground the singular judgment in the IEM cases; my account is meant to complement it by providing an answer to that ...
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Using Machine Learning Explainability Techniques to Examine Drivers of Ground Magnetic Field Localization

Space Weather
Solar wind particles interact with the Earth's magnetic field and can cause rapid changes in the magnetic field on the ground. This can result in Geomagnetically Induced Currents capable of causing significant damage to infrastructure, making it vital to
Michael Coughlan, Amy Keesee, Victor Pinto, Raman Mukundan, José Paulo Marchezi, Mayowa Adewuyi, Joel Tibbetts, Jeremiah Johnson, Hyunju Connor, Don Hampton   +9 more
doaj   +1 more source

Polarization and context: measuring and explaining political polarization in Brazil

, 2023
Mário Fuks, Pedro Henrique Marques
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Explainable embeddings with Distance Explainer

While eXplainable AI (XAI) has advanced significantly, few methods address interpretability in embedded vector spaces where dimensions represent complex abstractions. We introduce Distance Explainer, a novel method for generating local, post-hoc explanations of embedded spaces in machine learning models.
Meijer, Christiaan, Bos, E. G. Patrick
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source