Results 41 to 50 of about 4,042,759 (279)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Informatik-Spektrum, 2018 ,,Explainable AI“ ist kein neues Gebiet. Vielmehr ist das Problem der Erklarbarkeit so alt wie die AI selbst, ja vielmehr das Resultat ihrer selbst. Wahrend regelbasierte Losungen der fruhen AI nachvollziehbare ,,Glass-Box“-Ansatze darstellten, lag deren Schwache im Umgang mit Unsicherheiten der realen Welt.
openaire +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
On the road to explainable AI in drug-drug interactions prediction: A systematic review
Computational and Structural Biotechnology Journal, 2022 Over the past decade, polypharmacy instances have been common in multi-diseases treatment. However, unwanted drug-drug interactions (DDIs) that might cause unexpected adverse drug events (ADEs) in multiple regimens therapy remain a significant issue ...
Thanh Hoa Vo +3 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Survey of Explainable AI Techniques in Healthcare
Italian National Conference on Sensors, 2023 Artificial intelligence (AI) with deep learning models has been widely applied in numerous domains, including medical imaging and healthcare tasks. In the medical field, any judgment or decision is fraught with risk. A doctor will carefully judge whether
A. Chaddad +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Implications of causality in artificial intelligence
Frontiers in Artificial IntelligenceOver the last decade, investment in artificial intelligence (AI) has grown significantly, driven by technology companies and the demand for PhDs in AI. However, new challenges have emerged, such as the ‘black box’ and bias in AI models.
Luís Cavique
doaj +1 more source
Proceedings of the Conference on Fairness, Accountability, and Transparency, 2019 Recent work on interpretability in machine learning and AI has focused on the building of simplified models that approximate the true criteria used to make decisions. These models are a useful pedagogical device for teaching trained professionals how to predict what decisions will be made by the complex system, and most importantly how the system might
Mittelstadt, BD, Russell, C, Wachter, S
openaire +5 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source