Results 31 to 40 of about 5,977,377 (233)
eXplainable AI (XAI) -Lecture 2-
, 2021 Segona sessió del seminari impartit pel professor convidat Sebastian Lapuschkin, de l'Institut Fraunhofer de Berlin, sobre Explainable AI6584.mp4 6584 ...
Lapuschkin, Sebastian
core +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
eXplainable AI (XAI) -Lecture 3-
, 2021 Tercera sessió del seminari impartit pel professor convidat Sebastian Lapuschkin, de l'Institut Fraunhofer de Berlin, sobre Explainable AI6585.mp4 6585 ...
Lapuschkin, Sebastian
core +2 more sources
eXplainable AI (2023) - Sessió 3
, 2023 Tercera sessió del seminari impartit pel professor convidat Sebastian Lapuschkin, de l'Institut Fraunhofer de Berlin, sobre Explainable AIThird session of the seminar given by guest professor Sebastian Lapuschkin, Fraunhofer Institute Berlin, on ...
Lapuschkin, Sebastian
core +2 more sources
European Journal of MaterialsProcess-structure-properties linkages play a major role in materials and process engineering. Nowadays, such linkages are often established on the basis of experimental data and simulation data using machine learning approaches.
Rodrigo Iza Teran +2 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Explainable active reinforcement deep learning improves lung cancer detection from CT images
Scientific ReportsLung cancer remains a global health challenge that requires early and accurate diagnosis through medical imaging analysis. This study introduces ARXAF-Net framework which integrates Active Reinforcement deep leaning with strategic feature engineering ...
Ghada Nady +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source