Results 51 to 60 of about 5,977,377 (233)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Feature Engineering for Phishing Website Detection Using Machine Learning: A Systematic Review

IEEE Access
Phishing website detection has been widely explored, yet most existing surveys focus on detection algorithms or general cybersecurity methods, offering only a brief treatment of feature engineering. This systematic literature review addresses this gap by
Yanche Ari Kustiawan, Khairil Imran Ghauth   +1 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

eXplainable AI (2023) - Sessió 1

, 2023
Primera sessió del seminari impartit pel professor convidat Sebastian Lapuschkin, de l'Institut Fraunhofer de Berlin, sobre Explainable AIFirst session of the seminar given by guest professor Sebastian Lapuschkin, Fraunhofer Institute Berlin, on ...
Lapuschkin, Sebastian
core   +2 more sources

InteracTor: Feature engineering and explainable AI for profiling protein structure-interaction-function relationships.

PLoS Computational Biology
Characterizing protein families' structural and functional diversity is essential for understanding their biological roles. Traditional analyses often focus on primary and secondary structures, which may not fully capture complex protein interactions ...
Jose Cleydson F Silva, Layla Schuster, Nick Sexson, Melissa Erdem, Ryan Hulke, Matias Kirst, Marcio F R Resende, Raquel Dias   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Zipper Pattern: An Investigation into Psychotic Criminal Detection Using EEG Signals

Diagnostics
Background: Electroencephalography (EEG) signal-based machine learning models are among the most cost-effective methods for information retrieval.
Gulay Tasci, Prabal Datta Barua, Dahiru Tanko, Tugce Keles, Suat Tas, Ilknur Sercek, Suheda Kaya, Kubra Yildirim, Yunus Talu, Burak Tasci, Filiz Ozsoy, Nida Gonen, Irem Tasci, Sengul Dogan, Turker Tuncer   +14 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

XAI-Guided Graph-Based Feature Engineering and Heterogeneous Ensemble Learning for Android Malware Detection

Algorithms
Android malware continues to evolve in sophistication, creating a need for accurate, efficient, and interpretable detection mechanisms. This paper proposes a novel Android malware detection framework that integrates graph-based software engineering ...
Shahid Alam, Amina Jameel, Zahida Parveen, Ehab Alnfrawy, Anushya Alphonse, Imran Chaudhry, Jamal Ahmed   +6 more
doaj   +1 more source