Results 81 to 90 of about 5,977,377 (233)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Explainable AI based cervical cancer prediction using FSAE feature engineering and H2O AutoML

Scientific Reports
Cervical cancer, predominantly caused by Human Papillomavirus (HPV) infection, remains a significant global health burden for women, contributing to elevated morbidity and mortality rates.
Panneerselvam Karthikeyan, I. Malaserene, E. Deepakraj   +2 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Enriching Reverse Engineering with Feature Analysis [PDF]

, 2007
System comprehension is a prerequisite for software maintenance and evolution, but it is a time-consuming and costly activity. In an effort to support system comprehension, researchers have devised many different reverse engineering techniques.
Greevy, Orla
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Modeling students’ self-regulated learning from virtual reality-integrated e-module interaction data

Discover Artificial Intelligence
This study investigates how interaction data generated from virtual reality (VR)-integrated e-modules can be utilized to model students’ self-regulated learning (SRL) through an explainable machine learning approach.
Nurzengky Ibrahim, Desy Safitri, Arita Marini, Sujarwo Sujarwo, Asep Marfu   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Differential quadruple pattern: A new EEG signal classification framework

IBRO Neuroscience Reports
EEG signals are the letters of the brain and reflect neural activity. Abnormal EEG patterns indicate brain disorders such as epilepsy. Recently, machine learning has enabled automated EEG interpretation with high accuracy.
Bilge Ozgor, Omer Faruk Goktas, Mehmet Baygin, Sengul Dogan, Turker Tuncer   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An explainable EEG epilepsy detection model using friend pattern

Scientific Reports
The electroencephalography (EEG) signals are very important for obtaining information from the brain, and EEG signals are one of the cheapest methods to gather information from the brain. EEG signals have commonly been used to detect epilepsy. Therefore,
Turker Tuncer, Sengul Dogan
doaj   +1 more source