Results 91 to 100 of about 64,345 (254)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Transformer-Based Models for Probabilistic Time Series Forecasting with Explanatory Variables

Mathematics
Accurate demand forecasting is essential for retail operations as it directly impacts supply chain efficiency, inventory management, and financial performance. However, forecasting retail time series presents significant challenges due to their irregular
Ricardo Caetano, José Manuel Oliveira, Patrícia Ramos   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Filling in the implementation gap? Problems in the Greek educational system--An evidence-based explanatory framework and critical reflections

Current Issues in Education, 2011
The Greek educational system the last 50 years recounts among numerous reformations and counterreformations. All the continuous changes seem not to be characterized of a clearly defined operational aims and rational continuity. Nowadays Educators, pupils,
Argyris Kyridis, Nikos Papadakis, Christos Zagkos, Nikos Fotopoulos, Ageliki Chronopoulou   +4 more
doaj  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Perspectives on wolves after their recolonization in Flanders, Belgium

Royal Society Open Science
At the time of the wolf’s (Canis lupus) recolonization in Flanders, public perspectives on this species were not well understood. To address this gap, we conducted a survey gathering demographic and contextual data to explore the relationship between ...
Hilde Vervaecke, Thaana Van Dessel, Peter Galbusera, Joachim Mergeay   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Self-Evaluation in AI-Assisted Cognition: An Explanatory Framework for Calibration and Miscalibration Effects

Journal of Intelligence
Generative Artificial Intelligence (AI), particularly large language models, has changed the conditions under which individuals judge their own cognitive performance. While AI-assisted tools can improve task outcomes, such improvements do not necessarily
Monica Maier
doaj   +1 more source

Consciousness and brain: explanatory gap and ontological gap

, 2023
A questão sobre a qual se propôs refletir neste artigo é se, e em caso afirmativo, em que termos, uma abordagem fisicalista não reducionista e interacionista explica a relação entre consciência e cérebro. Para tanto, tomou-se como fio condutor o problema da lacuna explicativa em sua relação com o problema da lacuna ontológica, o que envolveu duas ...
openaire   +1 more source