Results 111 to 120 of about 2,716,887 (308)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Balance of payment crises in emerging markets: how early were the “early” warning signals? [PDF]

open access: yes
Although many papers have already proposed empirical models of currency crises, the timing of such crises has received relatively little attention so far.
Bussière, Matthieu
core  

Mary does not learn anything new: Applying Kim's critique of mental causation to the knowledge argument and the problem of consciousness [PDF]

open access: yes, 2019
Within the discourse surrounding mind-body interaction, mental causation is intimately associated with non-reductive physicalism. However, such a theory holds two opposing views: that all causal properties and relations can ...
Khayat, Adam
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Modeling Inflation Dynamics of the Iran’s Economy; P-Star Approach (Using ARDL and State-Space Models) [PDF]

open access: yesفصلنامه پژوهش‌های اقتصادی ایران, 2016
The association between money and prices has long been debated in various economic schools. Although there are different views, most economists agree that in the long run, inflation is a monetary phenomenon and its main cause is liquidity growth. Several
Reza Talebloo   +2 more
doaj  

Macro stress testing with sector specific bankruptcy models [PDF]

open access: yes, 2008
This paper employs the methodology of Wilson (1997) on Hungarian data to conduct a macro stress test in relation to banks' corporate loan portfolio. First, sector specific models of bankruptcy are estimated, where the bankruptcy frequency is linked to ...
Valentinyi-Endresz, Marianna   +1 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

How Long Does it Take to Integrate? Employment Convergence of Immigrants and Natives in Sweden. [PDF]

open access: yes
This study examines employment convergence between immigrants and natives, by gender and region of origin, using data with annual information (1990-2000) on more than 200,000 individuals of which over 19,000 were born abroad.
Nekby, Lena
core  

Research Brief: The Role of Tasks and Skills in Explaining the Disability Pay Gap [PDF]

open access: yes, 2014
A disparity in pay exists between workers with and without disabilities. This gap persists even in analyses that control for a variety of factors and incorporate compensation benefits other than wages and salaries.
Barrington, Linda   +3 more
core   +1 more source

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