Results 141 to 150 of about 2,716,887 (308)

Mind the explanatory gap: Quality from quantity [PDF]

, 2016
Bunn, JJ
core   +1 more source

Consciousness and brain: explanatory gap and ontological gap

, 2023
A questão sobre a qual se propôs refletir neste artigo é se, e em caso afirmativo, em que termos, uma abordagem fisicalista não reducionista e interacionista explica a relação entre consciência e cérebro. Para tanto, tomou-se como fio condutor o problema da lacuna explicativa em sua relação com o problema da lacuna ontológica, o que envolveu duas ...
openaire   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Optimization of Academic Services Based on Quality Function Deployment: An Integration Study of Servqual Method at Graha Nusantara University

Improvement: Jurnal Ilmiah Untuk Peningkatan Mutu Manajemen Pendidikan
This research is motivated by the need to improve academic service quality at Graha Nusantara University to meet student expectations and dynamic higher education industry demands.
Fitri Romaito Lubis, Martua Siregar, Yusniar Harahap, Bayo Harahap, Fitrah Suci Azzahra   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Making sense of transformer success

Frontiers in Artificial Intelligence
This article provides an epistemological analysis of current attempts of explaining how the relatively simple algorithmic components of neural language models (NLMs) provide them with genuine linguistic competence.
Nicola Angius, Pietro Perconti, Alessio Plebe, Alessandro Acciai   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Elephant in the Mirror: Bridging the Brain's Explanatory Gap of Consciousness. [PDF]

Front Syst Neurosci, 2016
Berry JA, Parker AC.
europepmc   +1 more source